Human Gene VEGFB (ENST00000309422.7) from GENCODE V44
Description: Homo sapiens vascular endothelial growth factor B (VEGFB), transcript variant VEGFB-186, mRNA. (from RefSeq NM_003377) RefSeq Summary (NM_003377): This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]. Gencode Transcript: ENST00000309422.7 Gencode Gene: ENSG00000173511.10 Transcript (Including UTRs) Position: hg38 chr11:64,234,584-64,239,264 Size: 4,681 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr11:64,234,834-64,237,633 Size: 2,800 Coding Exon Count: 6
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7LAP4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
