Human Gene KCNK4 (ENST00000538767.1) from GENCODE V44
Description: Homo sapiens potassium two pore domain channel subfamily K member 4 (KCNK4), transcript variant 4, non-coding RNA. (from RefSeq NR_133660) RefSeq Summary (NR_133660): This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. [provided by RefSeq, Nov 2015]. Gencode Transcript: ENST00000538767.1 Gencode Gene: ENSG00000182450.14 Transcript (Including UTRs) Position: hg38 chr11:64,291,325-64,300,028 Size: 8,704 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr11:64,296,888-64,299,824 Size: 2,937 Coding Exon Count: 5
ID:F5GYE0_HUMAN DESCRIPTION: SubName: Full=Potassium channel subfamily K member 4; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on F5GYE0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
AK309443 - Homo sapiens cDNA, FLJ99484. BC067791 - Homo sapiens potassium channel, subfamily K, member 4, mRNA (cDNA clone IMAGE:30345701), with apparent retained intron. AF259500 - Homo sapiens two pore K+ channel KT4.1a mRNA, complete cds. AK296021 - Homo sapiens cDNA FLJ56952 complete cds. JD395181 - Sequence 376205 from Patent EP1572962. JD407754 - Sequence 388778 from Patent EP1572962. JD276408 - Sequence 257432 from Patent EP1572962. AF247042 - Homo sapiens tandem pore domain potassium channel TRAAK (KCNK4) mRNA, complete cds. BC033577 - Homo sapiens potassium channel, subfamily K, member 4, mRNA (cDNA clone IMAGE:5200313). AF259501 - Homo sapiens two pore K+ channel KT4.1b mRNA, complete cds. BC110327 - Homo sapiens potassium channel, subfamily K, member 4, mRNA (cDNA clone IMAGE:5728354), partial cds. AF248242 - Homo sapiens 2P domain potassium channel (KCNK4) mRNA, complete cds. CU689656 - Synthetic construct Homo sapiens gateway clone IMAGE:100017985 5' read KCNK4 mRNA. KJ902532 - Synthetic construct Homo sapiens clone ccsbBroadEn_11926 KCNK4 gene, encodes complete protein. EU978935 - Homo sapiens K2P4.1 potassium channel (KCNK4) mRNA, complete cds. BC160128 - Synthetic construct Homo sapiens clone IMAGE:100064160, MGC:193243 potassium channel, subfamily K, member 4 (KCNK4) mRNA, encodes complete protein. JD053443 - Sequence 34467 from Patent EP1572962. JD125353 - Sequence 106377 from Patent EP1572962. JD412946 - Sequence 393970 from Patent EP1572962.
US Server
