Human Gene SCYL1 (ENST00000270176.10) from GENCODE V44
Description: Homo sapiens SCY1 like pseudokinase 1 (SCYL1), transcript variant A, mRNA. (from RefSeq NM_020680) RefSeq Summary (NM_020680): This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000270176.10 Gencode Gene: ENSG00000142186.18 Transcript (Including UTRs) Position: hg38 chr11:65,525,083-65,538,704 Size: 13,622 Total Exon Count: 18 Strand: + Coding Region Position: hg38 chr11:65,525,154-65,538,566 Size: 13,413 Coding Exon Count: 18
ID:NTKL_HUMAN DESCRIPTION: RecName: Full=N-terminal kinase-like protein; AltName: Full=Coated vesicle-associated kinase of 90 kDa; AltName: Full=SCY1-like protein 1; AltName: Full=Telomerase regulation-associated protein; AltName: Full=Telomerase transcriptional element-interacting factor; AltName: Full=Teratoma-associated tyrosine kinase; FUNCTION: Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro. FUNCTION: Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region. SUBUNIT: Interacts with GORAB. Interacts with COPA, COPB1 and COPB2 (By similarity). Homooligomer. Interacts with AP2B1. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Note=Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF1-independent manner. SUBCELLULAR LOCATION: Isoform 1: Cytoplasm. Note=Cytoplasmic throughout the cell cycle. SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. Note=Cytoplasmic throughout the cell cycle. SUBCELLULAR LOCATION: Isoform 3: Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Note=Cytoplasmic during interphase and centrosomal during mitosis, it localizes to the centrosomes in a microtubule-independent manner. SUBCELLULAR LOCATION: Isoform 6: Nucleus. TISSUE SPECIFICITY: Ubiquitous. DOMAIN: The protein kinase domain is predicted to be catalytically inactive. SIMILARITY: Belongs to the protein kinase superfamily. SIMILARITY: Contains 3 HEAT repeats. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=AAG09726.1; Type=Frameshift; Positions=289, 307; Sequence=AAG17902.1; Type=Frameshift; Positions=Several;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96KG9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
