Human Gene FIBP (ENST00000338369.6) from GENCODE V44
Description: Homo sapiens FGF1 intracellular binding protein (FIBP), transcript variant 1, mRNA. (from RefSeq NM_198897) RefSeq Summary (NM_198897): Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000338369.6 Gencode Gene: ENSG00000172500.13 Transcript (Including UTRs) Position: hg38 chr11:65,883,921-65,888,531 Size: 4,611 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr11:65,883,974-65,888,418 Size: 4,445 Coding Exon Count: 10
ID:FIBP_HUMAN DESCRIPTION: RecName: Full=Acidic fibroblast growth factor intracellular-binding protein; Short=aFGF intracellular-binding protein; AltName: Full=FGF-1 intracellular-binding protein; FUNCTION: May be involved in mitogenic function of FGF1. SUBUNIT: Binds to internalized FGF1. SUBCELLULAR LOCATION: Nucleus. Endomembrane system; Peripheral membrane protein. Note=Also associated with cytoplasmic membranes, particularly of mitochondria. TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle and pancreas. Expressed at lower levels in brain. Also found in placenta, liver and kidney. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/fibp/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43427
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
