Human Gene ARAP1 (ENST00000393609.8) from GENCODE V44
Description: Homo sapiens ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 (ARAP1), transcript variant 3, mRNA. (from RefSeq NM_001040118) RefSeq Summary (NM_001040118): The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]. Gencode Transcript: ENST00000393609.8 Gencode Gene: ENSG00000186635.16 Transcript (Including UTRs) Position: hg38 chr11:72,685,069-72,752,408 Size: 67,340 Total Exon Count: 35 Strand: - Coding Region Position: hg38 chr11:72,685,664-72,727,128 Size: 41,465 Coding Exon Count: 33
ID:ARAP1_HUMAN DESCRIPTION: RecName: Full=Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1; AltName: Full=Centaurin-delta-2; Short=Cnt-d2; FUNCTION: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity). SUBUNIT: Interacts with TNFRSF10A. INTERACTION: O00220:TNFRSF10A; NbExp=4; IntAct=EBI-710003, EBI-518861; P12956:XRCC6; NbExp=2; IntAct=EBI-710003, EBI-353208; SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane. Note=Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading. TISSUE SPECIFICITY: Detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and trachea. SIMILARITY: Contains 1 Arf-GAP domain. SIMILARITY: Contains 4 PH domains. SIMILARITY: Contains 1 Ras-associating domain. SIMILARITY: Contains 1 Rho-GAP domain. SIMILARITY: Contains 1 SAM (sterile alpha motif) domain. SEQUENCE CAUTION: Sequence=BAA34502.2; Type=Erroneous initiation; Sequence=BAD92710.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01412 - Putative GTPase activating protein for Arf PF00169 - PH domain PF00788 - Ras association (RalGDS/AF-6) domain PF00620 - RhoGAP domain PF00536 - SAM domain (Sterile alpha motif)
ModBase Predicted Comparative 3D Structure on Q96P48
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
