Human Gene MTNR1B (ENST00000257068.3) from GENCODE V44
Description: Homo sapiens melatonin receptor 1B (MTNR1B), mRNA. (from RefSeq NM_005959) RefSeq Summary (NM_005959): This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000257068.3 Gencode Gene: ENSG00000134640.3 Transcript (Including UTRs) Position: hg38 chr11:92,969,651-92,982,782 Size: 13,132 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr11:92,969,726-92,982,312 Size: 12,587 Coding Exon Count: 2
ID:MTR1B_HUMAN DESCRIPTION: RecName: Full=Melatonin receptor type 1B; Short=Mel-1B-R; Short=Mel1b receptor; FUNCTION: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in retina and less in brain and hippocampus. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. WEB RESOURCE: Name=Wikipedia; Note=Melatonin receptor entry; URL="http://en.wikipedia.org/wiki/Melatonin_receptor";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P49286
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.