Human Gene PANX3 (ENST00000284288.3) from GENCODE V44
  Description: Homo sapiens pannexin 3 (PANX3), mRNA. (from RefSeq NM_052959)
RefSeq Summary (NM_052959): The protein encoded by this gene belongs to the innexin family. Innexin family members are known to be the structural components of gap junctions. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000284288.3
Gencode Gene: ENSG00000154143.3
Transcript (Including UTRs)
   Position: hg38 chr11:124,611,428-124,620,356 Size: 8,929 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg38 chr11:124,611,557-124,619,935 Size: 8,379 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:124,611,428-124,620,356)mRNA (may differ from genome)Protein (392 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PANX3_HUMAN
DESCRIPTION: RecName: Full=Pannexin-3;
FUNCTION: Structural component of the gap junctions and the hemichannels.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (Potential). Cell junction, gap junction.
SIMILARITY: Belongs to the pannexin family.
WEB RESOURCE: Name=Wikipedia; Note=Pannexin entry; URL="http://en.wikipedia.org/wiki/Pannexin";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.39 RPKM in Testis
Total median expression: 1.15 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -37.80129-0.293 Picture PostScript Text
3' UTR -70.40421-0.167 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000990 - Innexin

Pfam Domains:
PF00876 - Innexin

ModBase Predicted Comparative 3D Structure on Q96QZ0
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0022829 wide pore channel activity
GO:0055077 gap junction hemi-channel activity

Biological Process:
GO:0006811 ion transport
GO:0006812 cation transport
GO:0007267 cell-cell signaling
GO:0034214 protein hexamerization
GO:0055085 transmembrane transport

Cellular Component:
GO:0005886 plasma membrane
GO:0005921 gap junction
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction


-  Descriptions from all associated GenBank mRNAs
  AB528788 - Synthetic construct DNA, clone: pF1KE0253, Homo sapiens PANX3 gene for pannexin 3, without stop codon, in Flexi system.
BC152944 - Synthetic construct Homo sapiens clone IMAGE:100016148, MGC:184213 pannexin 3 (PANX3) mRNA, encodes complete protein.
AF406650 - Homo sapiens putative gap junction protein pannexin 3 (PANX3) mRNA, complete cds.
JD042413 - Sequence 23437 from Patent EP1572962.
JD328487 - Sequence 309511 from Patent EP1572962.
JD496350 - Sequence 477374 from Patent EP1572962.
JD203009 - Sequence 184033 from Patent EP1572962.
JD516141 - Sequence 497165 from Patent EP1572962.
JD328857 - Sequence 309881 from Patent EP1572962.
JD423384 - Sequence 404408 from Patent EP1572962.
JD168046 - Sequence 149070 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000284288.1, ENST00000284288.2, NM_052959, PANX3_HUMAN, Q96QZ0, uc001qah.1, uc001qah.2, uc001qah.3, uc001qah.4, uc001qah.5
UCSC ID: ENST00000284288.3
RefSeq Accession: NM_052959
Protein: Q96QZ0 (aka PANX3_HUMAN or PAN3_HUMAN)
CCDS: CCDS8447.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.