Human Gene NTF3 (ENST00000423158.4) from GENCODE V44
Description: Homo sapiens neurotrophin 3 (NTF3), transcript variant 1, mRNA. (from RefSeq NM_001102654) RefSeq Summary (NM_001102654): The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000423158.4 Gencode Gene: ENSG00000185652.12 Transcript (Including UTRs) Position: hg38 chr12:5,432,108-5,495,299 Size: 63,192 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr12:5,432,325-5,494,988 Size: 62,664 Coding Exon Count: 2
ID:NTF3_HUMAN DESCRIPTION: RecName: Full=Neurotrophin-3; Short=NT-3; AltName: Full=HDNF; AltName: Full=Nerve growth factor 2; Short=NGF-2; AltName: Full=Neurotrophic factor; Flags: Precursor; FUNCTION: Seems to promote the survival of visceral and proprioceptive sensory neurons. INTERACTION: P23560:BDNF; NbExp=1; IntAct=EBI-1025994, EBI-1026003; SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Brain and peripheral tissues. POLYMORPHISM: Variant Glu-76 (frequently reported as Glu-63) was thought to be associated with severe forms of schizophrenia. This does not seem to be the case. SIMILARITY: Belongs to the NGF-beta family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P20783
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000187 activation of MAPK activity GO:0002092 positive regulation of receptor internalization GO:0007165 signal transduction GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007267 cell-cell signaling GO:0007399 nervous system development GO:0008284 positive regulation of cell proliferation GO:0010469 regulation of receptor activity GO:0030335 positive regulation of cell migration GO:0032148 activation of protein kinase B activity GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0042981 regulation of apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0045664 regulation of neuron differentiation GO:0048812 neuron projection morphogenesis GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation GO:0050918 positive chemotaxis GO:0050930 induction of positive chemotaxis GO:0090630 activation of GTPase activity GO:2000251 positive regulation of actin cytoskeleton reorganization