ID:CDCA3_HUMAN DESCRIPTION: RecName: Full=Cell division cycle-associated protein 3; AltName: Full=Gene-rich cluster protein C8; AltName: Full=Trigger of mitotic entry protein 1; Short=TOME-1; FUNCTION: F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity). PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with SKP1. Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytosol (By similarity). DOMAIN: The KEN box is required for the association with the APC/C-Cdh1 complex (By similarity). PTM: Ubiquitinated and degraded by the APC/C-Cdh1 complex (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q99618
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.