Human Gene TPI1 (ENST00000229270.8) from GENCODE V44
Description: D-glyceraldehyde 3-phosphate = glycerone phosphate. (from UniProt P60174) RefSeq Summary (NM_001159287): This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]. Gencode Transcript: ENST00000229270.8 Gencode Gene: ENSG00000111669.15 Transcript (Including UTRs) Position: hg38 chr12:6,867,119-6,870,948 Size: 3,830 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr12:6,867,456-6,870,383 Size: 2,928 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P60174
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006006 glucose metabolic process GO:0006094 gluconeogenesis GO:0006096 glycolytic process GO:0007275 multicellular organism development GO:0008152 metabolic process GO:0019563 glycerol catabolic process GO:0019682 glyceraldehyde-3-phosphate metabolic process GO:0046166 glyceraldehyde-3-phosphate biosynthetic process GO:0061621 canonical glycolysis
US Server
