Human Gene KRT79 (ENST00000330553.6) from GENCODE V44
  Description: Homo sapiens keratin 79 (KRT79), mRNA. (from RefSeq NM_175834)
RefSeq Summary (NM_175834): Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in skeletal muscle, skin and scalp. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009].
Gencode Transcript: ENST00000330553.6
Gencode Gene: ENSG00000185640.6
Transcript (Including UTRs)
   Position: hg38 chr12:52,821,408-52,834,311 Size: 12,904 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg38 chr12:52,821,872-52,834,260 Size: 12,389 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:52,821,408-52,834,311)mRNA (may differ from genome)Protein (535 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMGIneXtProtOMIM
PubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: K2C79_HUMAN
DESCRIPTION: RecName: Full=Keratin, type II cytoskeletal 79; AltName: Full=Cytokeratin-79; Short=CK-79; AltName: Full=Keratin-6-like; Short=Keratin-6L; AltName: Full=Keratin-79; Short=K79; AltName: Full=Type-II keratin Kb38;
SUBUNIT: Heterotetramer of two type I and two type II keratins.
TISSUE SPECIFICITY: Expressed in skeletal muscle, skin and scalp, but not in any other tissues or organs examined.
MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40- 55 and 56-70 kDa, respectively).
SIMILARITY: Belongs to the intermediate filament family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.32 RPKM in Skin - Not Sun Exposed (Suprapubic)
Total median expression: 18.64 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -6.7051-0.131 Picture PostScript Text
3' UTR -156.80464-0.338 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016044 - F
IPR001664 - IF
IPR018039 - Intermediate_filament_CS
IPR003054 - Keratin_II

Pfam Domains:
PF00038 - Intermediate filament protein

ModBase Predicted Comparative 3D Structure on Q5XKE5
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0019899 enzyme binding

Biological Process:
GO:0031424 keratinization
GO:0070268 cornification

Cellular Component:
GO:0005829 cytosol
GO:0005882 intermediate filament
GO:0045095 keratin filament
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AK130156 - Homo sapiens cDNA FLJ26646 fis, clone MPE04624.
AX721223 - Sequence 183 from Patent WO0220754.
BC063648 - Homo sapiens keratin 79, mRNA (cDNA clone MGC:75529 IMAGE:4804408), complete cds.
BC039148 - Homo sapiens keratin 79, mRNA (cDNA clone MGC:21767 IMAGE:4746574), complete cds.
AJ564105 - Homo sapiens mRNA for keratin 6L (KRT6L gene).
KJ900610 - Synthetic construct Homo sapiens clone ccsbBroadEn_10004 KRT79 gene, encodes complete protein.
JD393900 - Sequence 374924 from Patent EP1572962.
JD170751 - Sequence 151775 from Patent EP1572962.
JD487736 - Sequence 468760 from Patent EP1572962.
JD490443 - Sequence 471467 from Patent EP1572962.
JD108905 - Sequence 89929 from Patent EP1572962.
JD123370 - Sequence 104394 from Patent EP1572962.
JD271025 - Sequence 252049 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q5XKE5 (Reactome details) participates in the following event(s):

R-HSA-6805546 Keratin type I binds keratin type II
R-HSA-6805573 Keratin type I/type II heterodimers form tetramers
R-HSA-6806613 Keratin tetramers bind to form unit length filaments
R-HSA-6805567 Keratinization
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000330553.1, ENST00000330553.2, ENST00000330553.3, ENST00000330553.4, ENST00000330553.5, K2C79_HUMAN, K6L, KB38, KRT6L, NM_175834, Q5XKE5, Q6P465, Q7Z793, uc001sbb.1, uc001sbb.2, uc001sbb.3, uc001sbb.4, uc001sbb.5
UCSC ID: ENST00000330553.6
RefSeq Accession: NM_175834
Protein: Q5XKE5 (aka K2C79_HUMAN)
CCDS: CCDS8839.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.