ID:ZDH17_HUMAN DESCRIPTION: RecName: Full=Palmitoyltransferase ZDHHC17; EC=2.3.1.-; AltName: Full=Huntingtin yeast partner H; AltName: Full=Huntingtin-interacting protein 14; Short=HIP-14; AltName: Full=Huntingtin-interacting protein 3; Short=HIP-3; AltName: Full=Huntingtin-interacting protein H; AltName: Full=Putative MAPK-activating protein PM11; AltName: Full=Putative NF-kappa-B-activating protein 205; AltName: Full=Zinc finger DHHC domain-containing protein 17; Short=DHHC-17; FUNCTION: Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates Mg(2+) transport. CATALYTIC ACTIVITY: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.87 mM for for magnesium ions; SUBUNIT: Interacts (via ANK repeats) with HD. This interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease. INTERACTION: P60880:SNAP25; NbExp=3; IntAct=EBI-524753, EBI-524785; SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi membrane vesicles. TISSUE SPECIFICITY: Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney. ZDHHC17 is the only palmitoyltransferase in erythrocytes. DOMAIN: The DHHC domain is required for palmitoyltransferase activity. PTM: Autopalmitoylated. Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg(2+) transport. MISCELLANEOUS: The early and prominent pathology of HD is observed in the medium spiny neurons that project into the globus. SIMILARITY: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily. SIMILARITY: Contains 5 ANK repeats. SIMILARITY: Contains 1 DHHC-type zinc finger. SEQUENCE CAUTION: Sequence=AAF28972.1; Type=Frameshift; Positions=183, 191; Sequence=AAH30990.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAA76790.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAC77366.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC77388.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IUH5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0015095 magnesium ion transmembrane transporter activity GO:0016409 palmitoyltransferase activity GO:0016740 transferase activity GO:0016746 transferase activity, transferring acyl groups GO:0019706 protein-cysteine S-palmitoyltransferase activity GO:0042802 identical protein binding
Biological Process: GO:0018345 protein palmitoylation GO:0042953 lipoprotein transport GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:1903830 magnesium ion transmembrane transport