Human Gene KMT5A (ENST00000402868.8) from GENCODE V44
Description: Homo sapiens lysine methyltransferase 5A (KMT5A), transcript variant 5, non-coding RNA. (from RefSeq NR_136910) RefSeq Summary (NM_020382): The protein encoded by this gene is a protein-lysine N-methyltransferase that can monomethylate Lys-20 of histone H4 to effect transcriptional repression of some genes. The encoded protein is required for cell proliferation and plays a role in chromatin condensation. [provided by RefSeq, May 2016]. Gencode Transcript: ENST00000402868.8 Gencode Gene: ENSG00000183955.14 Transcript (Including UTRs) Position: hg38 chr12:123,384,132-123,409,353 Size: 25,222 Total Exon Count: 8 Strand: + Coding Region Position: hg38 chr12:123,384,199-123,407,703 Size: 23,505 Coding Exon Count: 8
ID:SETD8_HUMAN DESCRIPTION: RecName: Full=N-lysine methyltransferase SETD8; EC=2.1.1.-; AltName: Full=H4-K20-HMTase SETD8; AltName: Full=Histone-lysine N-methyltransferase SETD8; EC=2.1.1.43; AltName: Full=Lysine N-methyltransferase 5A; AltName: Full=PR/SET domain-containing protein 07; Short=PR-Set7; Short=PR/SET07; AltName: Full=SET domain-containing protein 8; FUNCTION: Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. SUBUNIT: Interacts with L3MBTL1. INTERACTION: P62805:HIST2H4B; NbExp=4; IntAct=EBI-1268946, EBI-302023; SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes. Associates with silent chromatin on euchromatic arms. Not associated with constitutive heterochromatin. DEVELOPMENTAL STAGE: Not detected during G1 phase. First detected during S through G2 phases, and peaks during mitosis (at protein level). INDUCTION: By HCFC1 C-terminal chain, independently of HCFC1 N- terminal chain. DOMAIN: Although the SET domain contains the active site of enzymatic activity, both sequences upstream and downstream of the SET domain are required for methyltransferase activity. SIMILARITY: Belongs to the histone-lysine methyltransferase family. PR/SET subfamily. SIMILARITY: Contains 1 SET domain. CAUTION: It is uncertain whether Met-1 or Met-72 is the initiator. SEQUENCE CAUTION: Sequence=AAL40879.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NQR1
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006325 chromatin organization GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0007049 cell cycle GO:0018026 peptidyl-lysine monomethylation GO:0032259 methylation GO:0034770 histone H4-K20 methylation GO:0034968 histone lysine methylation GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator GO:0045892 negative regulation of transcription, DNA-templated GO:0051301 cell division GO:1901796 regulation of signal transduction by p53 class mediator
US Server
