Human Gene TNFRSF19 (ENST00000382258.8) from GENCODE V44
Description: Homo sapiens TNF receptor superfamily member 19 (TNFRSF19), transcript variant 1, mRNA. (from RefSeq NM_018647) RefSeq Summary (NM_018647): The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000382258.8 Gencode Gene: ENSG00000127863.16 Transcript (Including UTRs) Position: hg38 chr13:23,579,360-23,669,273 Size: 89,914 Total Exon Count: 9 Strand: + Coding Region Position: hg38 chr13:23,590,184-23,669,124 Size: 78,941 Coding Exon Count: 8
ID:TNR19_HUMAN DESCRIPTION: RecName: Full=Tumor necrosis factor receptor superfamily member 19; AltName: Full=TRADE; AltName: Full=Toxicity and JNK inducer; Flags: Precursor; FUNCTION: Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death. SUBUNIT: Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Probable). TISSUE SPECIFICITY: Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes. SIMILARITY: Contains 3 TNFR-Cys repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NS68
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.