Human Gene RPL21 (ENST00000311549.11) from GENCODE V44
  Description: Homo sapiens ribosomal protein L21 (RPL21), mRNA. (from RefSeq NM_000982)
RefSeq Summary (NM_000982): Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L21E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000311549.11
Gencode Gene: ENSG00000122026.11
Transcript (Including UTRs)
   Position: hg38 chr13:27,251,558-27,256,568 Size: 5,011 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chr13:27,253,777-27,256,525 Size: 2,749 Coding Exon Count: 5 

Page IndexSequence and LinksPrimersMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:27,251,558-27,256,568)mRNA (may differ from genome)Protein (160 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDMalacardsMGIOMIMPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: RPL21
Diseases sorted by gene-association score: hypotrichosis 12* (1328), hypotrichosis simplex* (184), hypotrichosis (10)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.10 RPKM in Ovary
Total median expression: 309.51 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -4.1040-0.102 Picture PostScript Text
3' UTR -2.5043-0.058 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001147 - Ribosomal_L21e
IPR018259 - Ribosomal_L21e_CS
IPR008991 - Translation_prot_SH3-like

Pfam Domains:
PF01157 - Ribosomal protein L21e

ModBase Predicted Comparative 3D Structure on Q6IAX2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI     
Protein Sequence     
Alignment     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003735 structural constituent of ribosome

Biological Process:
GO:0006412 translation

Cellular Component:
GO:0005622 intracellular
GO:0005840 ribosome


-  Descriptions from all associated GenBank mRNAs
  D28406 - Homo sapiens mRNA for ribosomal protein L21 homologue, 5'UTR region.
BC070185 - Homo sapiens similar to 60S ribosomal protein L21, mRNA (cDNA clone IMAGE:6653881).
AK311795 - Homo sapiens cDNA, FLJ92056, Homo sapiens ribosomal protein L21 (RPL21), mRNA.
BC070323 - Homo sapiens ribosomal protein L21, mRNA (cDNA clone MGC:88326 IMAGE:4248655), complete cds.
BC070330 - Homo sapiens ribosomal protein L21, mRNA (cDNA clone MGC:88334 IMAGE:3931616), complete cds.
BC104667 - Homo sapiens ribosomal protein L21, mRNA (cDNA clone MGC:104275 IMAGE:6724053), complete cds.
AK130968 - Homo sapiens cDNA FLJ27458 fis, clone DMC06607, highly similar to 60S ribosomal protein L21.
BX647669 - Homo sapiens mRNA; cDNA DKFZp686C06101 (from clone DKFZp686C06101).
LF205235 - JP 2014500723-A/12738: Polycomb-Associated Non-Coding RNAs.
MA440812 - JP 2018138019-A/12738: Polycomb-Associated Non-Coding RNAs.
LF206046 - JP 2014500723-A/13549: Polycomb-Associated Non-Coding RNAs.
MA441623 - JP 2018138019-A/13549: Polycomb-Associated Non-Coding RNAs.
LF205730 - JP 2014500723-A/13233: Polycomb-Associated Non-Coding RNAs.
MA441307 - JP 2018138019-A/13233: Polycomb-Associated Non-Coding RNAs.
AY320407 - Homo sapiens nasopharyngeal carcinoma-associated antigen mRNA sequence.
LF210938 - JP 2014500723-A/18441: Polycomb-Associated Non-Coding RNAs.
MA446515 - JP 2018138019-A/18441: Polycomb-Associated Non-Coding RNAs.
U25789 - Human ribosomal protein L21 mRNA, complete cds.
LF208995 - JP 2014500723-A/16498: Polycomb-Associated Non-Coding RNAs.
MA444572 - JP 2018138019-A/16498: Polycomb-Associated Non-Coding RNAs.
BC104478 - Homo sapiens ribosomal protein L21, mRNA (cDNA clone IMAGE:6605832).
L25348 - Homo sapiens ribosomal protein L21 (homologue of rat rpL21) mRNA fragment.
U14967 - Human ribosomal protein L21 mRNA, complete cds.
BC070184 - Homo sapiens ribosomal protein L21, mRNA (cDNA clone MGC:88165 IMAGE:4281405), complete cds.
BC001603 - Homo sapiens ribosomal protein L21, mRNA (cDNA clone MGC:2150 IMAGE:3543702), complete cds.
X89401 - H.sapiens mRNA for large subunit of ribosomal protein L21.
LF209843 - JP 2014500723-A/17346: Polycomb-Associated Non-Coding RNAs.
MA445420 - JP 2018138019-A/17346: Polycomb-Associated Non-Coding RNAs.
BC062981 - Homo sapiens ribosomal protein L21, mRNA (cDNA clone MGC:71252 IMAGE:6084268), complete cds.
BC071902 - Homo sapiens ribosomal protein L21, mRNA (cDNA clone MGC:88581 IMAGE:4901492), complete cds.
LF207891 - JP 2014500723-A/15394: Polycomb-Associated Non-Coding RNAs.
MA443468 - JP 2018138019-A/15394: Polycomb-Associated Non-Coding RNAs.
BC007505 - Homo sapiens ribosomal protein L21, mRNA (cDNA clone MGC:4136 IMAGE:2964441), complete cds.
KJ892030 - Synthetic construct Homo sapiens clone ccsbBroadEn_01424 RPL21 gene, encodes complete protein.
CR457032 - Homo sapiens full open reading frame cDNA clone RZPDo834D0315D for gene RPL21, ribosomal protein L21; complete cds, incl. stopcodon.
BC019002 - Homo sapiens ribosomal protein L21, mRNA (cDNA clone IMAGE:4543963).
AF086172 - Homo sapiens full length insert cDNA clone ZB89E10.
LF332458 - JP 2014500723-A/139961: Polycomb-Associated Non-Coding RNAs.
MA568035 - JP 2018138019-A/139961: Polycomb-Associated Non-Coding RNAs.
LF324899 - JP 2014500723-A/132402: Polycomb-Associated Non-Coding RNAs.
MA560476 - JP 2018138019-A/132402: Polycomb-Associated Non-Coding RNAs.
LF371039 - JP 2014500723-A/178542: Polycomb-Associated Non-Coding RNAs.
MA606616 - JP 2018138019-A/178542: Polycomb-Associated Non-Coding RNAs.
DQ594786 - Homo sapiens piRNA piR-60898, complete sequence.
LF332045 - JP 2014500723-A/139548: Polycomb-Associated Non-Coding RNAs.
MA567622 - JP 2018138019-A/139548: Polycomb-Associated Non-Coding RNAs.
LF350806 - JP 2014500723-A/158309: Polycomb-Associated Non-Coding RNAs.
MA586383 - JP 2018138019-A/158309: Polycomb-Associated Non-Coding RNAs.
JD284643 - Sequence 265667 from Patent EP1572962.
LF332459 - JP 2014500723-A/139962: Polycomb-Associated Non-Coding RNAs.
LF342330 - JP 2014500723-A/149833: Polycomb-Associated Non-Coding RNAs.
MA568036 - JP 2018138019-A/139962: Polycomb-Associated Non-Coding RNAs.
MA577907 - JP 2018138019-A/149833: Polycomb-Associated Non-Coding RNAs.
LF318451 - JP 2014500723-A/125954: Polycomb-Associated Non-Coding RNAs.
MA554028 - JP 2018138019-A/125954: Polycomb-Associated Non-Coding RNAs.
LF369918 - JP 2014500723-A/177421: Polycomb-Associated Non-Coding RNAs.
MA605495 - JP 2018138019-A/177421: Polycomb-Associated Non-Coding RNAs.
DQ570996 - Homo sapiens piRNA piR-31108, complete sequence.
JD450959 - Sequence 431983 from Patent EP1572962.
DQ580106 - Homo sapiens piRNA piR-48218, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000311549.1, ENST00000311549.10, ENST00000311549.2, ENST00000311549.3, ENST00000311549.4, ENST00000311549.5, ENST00000311549.6, ENST00000311549.7, ENST00000311549.8, ENST00000311549.9, hCG_2020044, NM_000982, Q6IAX2, Q6IAX2_HUMAN, RP11-428O18.5-001, uc001ura.1, uc001ura.2, uc001ura.3, uc001ura.4, uc001ura.5
UCSC ID: ENST00000311549.11
RefSeq Accession: NM_000982
Protein: Q6IAX2

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.