Human Gene CNMD (ENST00000377962.8) from GENCODE V44
Description: Homo sapiens chondromodulin (CNMD), transcript variant 1, mRNA. (from RefSeq NM_007015) RefSeq Summary (NM_007015): This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000377962.8 Gencode Gene: ENSG00000136110.13 Transcript (Including UTRs) Position: hg38 chr13:52,703,264-52,739,820 Size: 36,557 Total Exon Count: 7 Strand: - Coding Region Position: hg38 chr13:52,703,595-52,739,701 Size: 36,107 Coding Exon Count: 7
ID:LECT1_HUMAN DESCRIPTION: RecName: Full=Leukocyte cell-derived chemotaxin 1; Contains: RecName: Full=Chondrosurfactant protein; Short=CH-SP; Contains: RecName: Full=Chondromodulin-1; AltName: Full=Chondromodulin-I; Short=ChM-I; Flags: Precursor; FUNCTION: Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization. SUBCELLULAR LOCATION: Chondromodulin-1: Secreted. Note=Accumulated in the inter-territorial matrix of cartilage. SUBCELLULAR LOCATION: Chondrosurfactant protein: Endomembrane system; Single-pass membrane protein (Potential). TISSUE SPECIFICITY: Detected in cartilage and cardiac valves (at protein level). Detected in the laminae fibrosa, spongiosa and ventricularis layers of normal cardiac valves (at protein level). Expression is decreased cardiac valves of patients with valvular heart disease (at protein level). Weakly expressed in chondrosarcoma. DEVELOPMENTAL STAGE: Expressed at 9 weeks in developing cartilagenous bone rudiments. PTM: After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein. SIMILARITY: Belongs to the chondromodulin-1 family. SIMILARITY: Contains 1 BRICHOS domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75829
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.