Human Gene SCEL (ENST00000349847.4) from GENCODE V44
Description: Homo sapiens sciellin (SCEL), transcript variant 1, mRNA. (from RefSeq NM_144777) RefSeq Summary (NM_144777): The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated keratinocytes. This protein localizes to the periphery of cells and may function in the assembly or regulation of proteins in the cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant utilizing an alternative polyA signal has been described in the literature, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000349847.4 Gencode Gene: ENSG00000136155.17 Transcript (Including UTRs) Position: hg38 chr13:77,535,706-77,645,263 Size: 109,558 Total Exon Count: 33 Strand: + Coding Region Position: hg38 chr13:77,555,876-77,644,274 Size: 88,399 Coding Exon Count: 32
ID:SCEL_HUMAN DESCRIPTION: RecName: Full=Sciellin; FUNCTION: May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope. SUBCELLULAR LOCATION: Cytoplasm. Membrane. Note=May become cross- linked to membrane proteins by transglutaminase. TISSUE SPECIFICITY: Highly expressed in esophagus. It is also expressed in keratinocytes, amniotic tissue, foreskin stratum spinosum and stratum granulosum, hair follicle and nail. SIMILARITY: Contains 1 LIM zinc-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95171
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0008544 epidermis development GO:0009612 response to mechanical stimulus GO:0009792 embryo development ending in birth or egg hatching GO:0030216 keratinocyte differentiation GO:0090263 positive regulation of canonical Wnt signaling pathway
US Server
