Human Gene SLITRK1 (ENST00000377084.3) from GENCODE V44
Description: Homo sapiens SLIT and NTRK like family member 1 (SLITRK1), transcript variant 1, mRNA. (from RefSeq NM_052910) RefSeq Summary (NM_052910): This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]. Gencode Transcript: ENST00000377084.3 Gencode Gene: ENSG00000178235.8 Transcript (Including UTRs) Position: hg38 chr13:83,877,205-83,882,393 Size: 5,189 Total Exon Count: 1 Strand: - Coding Region Position: hg38 chr13:83,879,417-83,881,507 Size: 2,091 Coding Exon Count: 1
ID:SLIK1_HUMAN DESCRIPTION: RecName: Full=SLIT and NTRK-like protein 1; AltName: Full=Leucine-rich repeat-containing protein 12; Flags: Precursor; FUNCTION: Enhances neuronal dendrite outgrowth. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). TISSUE SPECIFICITY: Expressed predominantly in the frontal lobe of the cerebral cortex of the brain. Also expressed in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors. DEVELOPMENTAL STAGE: At 20 weeks of gestation, expressed in multiple brain regions, including the developing neo-cortical plate, subplate zone, striatum, globus pallidus, thalamus and subthalamus. DISEASE: Defects in SLITRK1 may be a cause of Gilles de la Tourette syndrome (GTS) [MIM:137580]. GTS is a neurologic disorder manifested particularly by motor and vocal tics and associated with behavioral abnormalities. DISEASE: Defects in SLITRK1 may be a cause of trichotillomania (TTM) [MIM:613229]. It is a neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. Affected individuals may develop physical complications and often have overlapping psychologic disorders, such as Gilles de la Tourette syndrome or obsessive-compulsive disorder. SIMILARITY: Belongs to the SLITRK family. SIMILARITY: Contains 12 LRR (leucine-rich) repeats. SIMILARITY: Contains 2 LRRCT domains. SIMILARITY: Contains 2 LRRNT domains. SEQUENCE CAUTION: Sequence=BAB67803.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96PX8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.