Human Gene ANG (ENST00000397990.4) Description and Page Index
  Description: Homo sapiens angiogenin (ANG), transcript variant 2, mRNA. (from RefSeq NM_001097577)
RefSeq Summary (NM_001097577): The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. In addition, the mature peptide has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2014].
Gencode Transcript: ENST00000397990.4
Gencode Gene: ENSG00000214274.9
Transcript (Including UTRs)
   Position: hg38 chr14:20,688,773-20,694,186 Size: 5,414 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg38 chr14:20,693,565-20,694,008 Size: 444 Coding Exon Count: 1 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionRNA Structure
Other SpeciesmRNA DescriptionsOther NamesGeneReviewsMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:20,688,773-20,694,186)mRNA (may differ from genome)Protein (147 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGIOMIMPubMedStanford SOURCEUniProtKB
Wikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: ANG
Diseases sorted by gene-association score: amyotrophic lateral sclerosis 9* (1235), amyotrophic lateral sclerosis 1* (134), ang-related amyotrophic lateral sclerosis* (100), venezuelan hemorrhagic fever (15), lateral sclerosis (11), heart tumor (10), lipodermatosclerosis (8), amyotrophic lateral sclerosis 11 (6), bladder squamous cell carcinoma (6), amyotrophic lateral sclerosis 7 (5), amyotrophic lateral sclerosis type 10 (5), female stress incontinence (4)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.28 RPKM in Liver
Total median expression: 7.43 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -31.80120-0.265 Picture PostScript Text
3' UTR -41.30178-0.232 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI Ensembl   
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  FJ236304 - Homo sapiens epididymis luminal protein 168 (HEL168) mRNA, complete cds.
LF384987 - JP 2014500723-A/192490: Polycomb-Associated Non-Coding RNAs.
MA620564 - JP 2018138019-A/192490: Polycomb-Associated Non-Coding RNAs.
AK313989 - Homo sapiens cDNA, FLJ94641, Homo sapiens angiogenin, ribonuclease, RNase A family, 5 (ANG),mRNA.
BC054880 - Homo sapiens angiogenin, ribonuclease, RNase A family, 5, mRNA (cDNA clone MGC:61969 IMAGE:6453640), complete cds.
BX248010 - human full-length cDNA clone CS0DM007YH13 of Fetal liver of Homo sapiens (human).
BC062698 - Homo sapiens angiogenin, ribonuclease, RNase A family, 5, mRNA (cDNA clone MGC:71966 IMAGE:4716820), complete cds.
BC020704 - Homo sapiens angiogenin, ribonuclease, RNase A family, 5, mRNA (cDNA clone MGC:22466 IMAGE:4716144), complete cds.
CU691108 - Synthetic construct Homo sapiens gateway clone IMAGE:100022354 5' read ANG mRNA.
AB591017 - Synthetic construct DNA, clone: pFN21AE1631, Homo sapiens ANG gene for angiogenin, ribonuclease, RNase A family, 5, without stop codon, in Flexi system.
CR407633 - Homo sapiens full open reading frame cDNA clone RZPDo834E012D for gene RNASE4, ribonuclease, RNase A family, 4 complete cds, without stopcodon.
CU687594 - Synthetic construct Homo sapiens gateway clone IMAGE:100023050 5' read ANG mRNA.
HQ447651 - Synthetic construct Homo sapiens clone IMAGE:100070997; CCSB013328_01 angiogenin, ribonuclease, RNase A family, 5 (ANG) gene, encodes complete protein.
KJ890672 - Synthetic construct Homo sapiens clone ccsbBroadEn_00066 ANG gene, encodes complete protein.
KJ896420 - Synthetic construct Homo sapiens clone ccsbBroadEn_05814 ANG gene, encodes complete protein.
KR711289 - Synthetic construct Homo sapiens clone CCSBHm_00022375 ANG (ANG) mRNA, encodes complete protein.
KR711290 - Synthetic construct Homo sapiens clone CCSBHm_00022381 ANG (ANG) mRNA, encodes complete protein.
KR711291 - Synthetic construct Homo sapiens clone CCSBHm_00022384 ANG (ANG) mRNA, encodes complete protein.
KR711292 - Synthetic construct Homo sapiens clone CCSBHm_00022385 ANG (ANG) mRNA, encodes complete protein.
LF334362 - JP 2014500723-A/141865: Polycomb-Associated Non-Coding RNAs.
MA569939 - JP 2018138019-A/141865: Polycomb-Associated Non-Coding RNAs.
JD408414 - Sequence 389438 from Patent EP1572962.
JD311799 - Sequence 292823 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001097577, uc001vxz.1, uc001vxz.2, uc001vxz.3, W0UV28
UCSC ID: uc001vxz.3
RefSeq Accession: NM_001097577
CCDS: CCDS9554.1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene ANG:
als-overview (Amyotrophic Lateral Sclerosis Overview)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.