Human Gene ANG (ENST00000397990.4) Description and Page Index
Description: Homo sapiens angiogenin (ANG), transcript variant 2, mRNA. (from RefSeq NM_001097577) RefSeq Summary (NM_001097577): The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. In addition, the mature peptide has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2014]. Gencode Transcript: ENST00000397990.4 Gencode Gene: ENSG00000214274.9 Transcript (Including UTRs) Position: hg38 chr14:20,688,773-20,694,186 Size: 5,414 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr14:20,693,565-20,694,008 Size: 444 Coding Exon Count: 1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.