Human Gene ADCY4 (ENST00000310677.8) from GENCODE V44
Description: This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (By similarity). (from UniProt Q8NFM4) RefSeq Summary (NM_139247): This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]. Gencode Transcript: ENST00000310677.8 Gencode Gene: ENSG00000129467.14 Transcript (Including UTRs) Position: hg38 chr14:24,318,349-24,335,071 Size: 16,723 Total Exon Count: 26 Strand: - Coding Region Position: hg38 chr14:24,318,416-24,334,652 Size: 16,237 Coding Exon Count: 25
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF06327 - Domain of Unknown Function (DUF1053) PF00211 - Adenylate and Guanylate cyclase catalytic domain
ModBase Predicted Comparative 3D Structure on Q8NFM4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein Q8NFM4 (Reactome details) participates in the following event(s):
R-HSA-163617 G alpha (s) activates adenylate cyclase R-HSA-170672 Galpha-olf:GTP binds to adenylate cyclase and activates it R-HSA-392064 G alpha (z) inhibits adenylate cyclase R-HSA-392206 G alpha (i) inhibits adenylate cyclase R-HSA-170674 Dissociation of the Gi alpha:G olf complex R-HSA-170677 The G alpha-olf:GDP:Adenylate cyclase complex dissociates R-HSA-170685 Adenylaye cyclase increases the GTPase activity of G alpha-olf R-HSA-170686 Adenylate cyclase increases the GTPase activity of Gi alpha R-HSA-170671 G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex R-HSA-111930 Adenylate cyclase produces cAMP R-HSA-392129 Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate R-HSA-5610727 GPR161 promotes cAMP production in a G alpha(s)-dependent manner R-HSA-164377 Activated Adenylate cyclase catalyses cAMP synthesis R-HSA-170676 Adenylate cyclase converts ATP into cyclic AMP R-HSA-170666 Adenylate cyclase increases the GTPase activity of G alpha-olf R-HSA-163359 Glucagon signaling in metabolic regulation R-HSA-418555 G alpha (s) signalling events R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-170660 Adenylate cyclase activating pathway R-HSA-418597 G alpha (z) signalling events R-HSA-170670 Adenylate cyclase inhibitory pathway R-HSA-418594 G alpha (i) signalling events R-HSA-163685 Energy Metabolism R-HSA-388396 GPCR downstream signalling R-HSA-445717 Aquaporin-mediated transport R-HSA-112040 G-protein mediated events R-HSA-997269 Inhibition of adenylate cyclase pathway R-HSA-163615 PKA activation R-HSA-5610787 Hedgehog 'off' state R-HSA-164378 PKA activation in glucagon signalling R-HSA-1430728 Metabolism R-HSA-372790 Signaling by GPCR R-HSA-382551 Transport of small molecules R-HSA-111885 Opioid Signalling R-HSA-991365 Activation of GABAB receptors R-HSA-111931 PKA-mediated phosphorylation of CREB R-HSA-5358351 Signaling by Hedgehog R-HSA-162582 Signal Transduction R-HSA-977444 GABA B receptor activation R-HSA-111933 Calmodulin induced events R-HSA-977443 GABA receptor activation R-HSA-111997 CaM pathway R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-111996 Ca-dependent events R-HSA-1489509 DAG and IP3 signaling R-HSA-112315 Transmission across Chemical Synapses R-HSA-112043 PLC beta mediated events R-HSA-9006925 Intracellular signaling by second messengers R-HSA-112316 Neuronal System
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