Human Gene RPS29 (ENST00000396020.7) from GENCODE V44
Description: Homo sapiens ribosomal protein S29 (RPS29), transcript variant 2, mRNA. (from RefSeq NM_001030001) RefSeq Summary (NM_001030001): Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit and a member of the S14P family of ribosomal proteins. The protein, which contains a C2-C2 zinc finger-like domain that can bind to zinc, can enhance the tumor suppressor activity of Ras-related protein 1A (KREV1). It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]. Gencode Transcript: ENST00000396020.7 Gencode Gene: ENSG00000213741.11 Transcript (Including UTRs) Position: hg38 chr14:49,570,984-49,586,376 Size: 15,393 Total Exon Count: 3 Strand: - Coding Region Position: hg38 chr14:49,577,812-49,586,346 Size: 8,535 Coding Exon Count: 3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00253 - Ribosomal protein S14p/S29e
ModBase Predicted Comparative 3D Structure on P62273
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK055143 - Homo sapiens cDNA FLJ30581 fis, clone BRAWH2007069. JD203108 - Sequence 184132 from Patent EP1572962. JD051710 - Sequence 32734 from Patent EP1572962. JD189006 - Sequence 170030 from Patent EP1572962. JD091708 - Sequence 72732 from Patent EP1572962. JD563264 - Sequence 544288 from Patent EP1572962. JD358247 - Sequence 339271 from Patent EP1572962. JD300672 - Sequence 281696 from Patent EP1572962. JD305842 - Sequence 286866 from Patent EP1572962. JD236564 - Sequence 217588 from Patent EP1572962. JD309504 - Sequence 290528 from Patent EP1572962. JD525115 - Sequence 506139 from Patent EP1572962. JD364018 - Sequence 345042 from Patent EP1572962. JD113753 - Sequence 94777 from Patent EP1572962. JD312601 - Sequence 293625 from Patent EP1572962. JD112261 - Sequence 93285 from Patent EP1572962. JD395606 - Sequence 376630 from Patent EP1572962. JD089467 - Sequence 70491 from Patent EP1572962. JD442260 - Sequence 423284 from Patent EP1572962. JD522488 - Sequence 503512 from Patent EP1572962. JD289018 - Sequence 270042 from Patent EP1572962. JD289019 - Sequence 270043 from Patent EP1572962. JD446878 - Sequence 427902 from Patent EP1572962. JD512814 - Sequence 493838 from Patent EP1572962. JD412838 - Sequence 393862 from Patent EP1572962. JD197832 - Sequence 178856 from Patent EP1572962. JD396853 - Sequence 377877 from Patent EP1572962. JD536384 - Sequence 517408 from Patent EP1572962. JD426586 - Sequence 407610 from Patent EP1572962. JD544971 - Sequence 525995 from Patent EP1572962. JD431451 - Sequence 412475 from Patent EP1572962. JD164604 - Sequence 145628 from Patent EP1572962. JD244897 - Sequence 225921 from Patent EP1572962. JD381340 - Sequence 362364 from Patent EP1572962. JD069563 - Sequence 50587 from Patent EP1572962. JD535425 - Sequence 516449 from Patent EP1572962. JD249493 - Sequence 230517 from Patent EP1572962. JD232403 - Sequence 213427 from Patent EP1572962. JD427680 - Sequence 408704 from Patent EP1572962. JD061285 - Sequence 42309 from Patent EP1572962. JD262942 - Sequence 243966 from Patent EP1572962. JD415124 - Sequence 396148 from Patent EP1572962. JD525295 - Sequence 506319 from Patent EP1572962. JD488107 - Sequence 469131 from Patent EP1572962. JD294969 - Sequence 275993 from Patent EP1572962. JD415123 - Sequence 396147 from Patent EP1572962. JD415121 - Sequence 396145 from Patent EP1572962. JD325179 - Sequence 306203 from Patent EP1572962. JD254597 - Sequence 235621 from Patent EP1572962. JD080472 - Sequence 61496 from Patent EP1572962. JD375479 - Sequence 356503 from Patent EP1572962. JD205333 - Sequence 186357 from Patent EP1572962. JD243646 - Sequence 224670 from Patent EP1572962. JD333342 - Sequence 314366 from Patent EP1572962. JD207700 - Sequence 188724 from Patent EP1572962. JD072372 - Sequence 53396 from Patent EP1572962. JD225389 - Sequence 206413 from Patent EP1572962. JD345714 - Sequence 326738 from Patent EP1572962. JD133168 - Sequence 114192 from Patent EP1572962. JD089484 - Sequence 70508 from Patent EP1572962. JD216161 - Sequence 197185 from Patent EP1572962. JD421894 - Sequence 402918 from Patent EP1572962. JD247017 - Sequence 228041 from Patent EP1572962. JD413445 - Sequence 394469 from Patent EP1572962. JD498027 - Sequence 479051 from Patent EP1572962. JD376139 - Sequence 357163 from Patent EP1572962. JD454132 - Sequence 435156 from Patent EP1572962. JD451219 - Sequence 432243 from Patent EP1572962. JD308303 - Sequence 289327 from Patent EP1572962. JD441447 - Sequence 422471 from Patent EP1572962. JD564437 - Sequence 545461 from Patent EP1572962. AK307833 - Homo sapiens cDNA, FLJ97781. JD364150 - Sequence 345174 from Patent EP1572962. JD554507 - Sequence 535531 from Patent EP1572962. JD415285 - Sequence 396309 from Patent EP1572962. JD514053 - Sequence 495077 from Patent EP1572962. JD533938 - Sequence 514962 from Patent EP1572962. JD059614 - Sequence 40638 from Patent EP1572962. BC015974 - Homo sapiens ribosomal protein S29, mRNA (cDNA clone MGC:23746 IMAGE:4105424), complete cds. JD028544 - Sequence 9568 from Patent EP1572962. JD021273 - Sequence 2297 from Patent EP1572962. BC035313 - Homo sapiens ribosomal protein S29, mRNA (cDNA clone MGC:9279 IMAGE:3868721), complete cds. BC032813 - Homo sapiens ribosomal protein S29, mRNA (cDNA clone MGC:44919 IMAGE:5217083), complete cds. AK026649 - Homo sapiens cDNA: FLJ22996 fis, clone KAT11938. L31610 - Homo sapiens (clone cori-1cl5) S29 ribosomal protein mRNA, complete cds. U14973 - Human ribosomal protein S29 mRNA, complete cds. DQ896685 - Synthetic construct Homo sapiens clone IMAGE:100011145; FLH196657.01L; RZPDo839F04155D ribosomal protein S29 (RPS29) gene, encodes complete protein. EU176460 - Synthetic construct Homo sapiens clone IMAGE:100006635; FLH264112.01X; RZPDo839E09257D ribosomal protein S29 (RPS29) gene, encodes complete protein. KJ892071 - Synthetic construct Homo sapiens clone ccsbBroadEn_01465 RPS29 gene, encodes complete protein. JD292611 - Sequence 273635 from Patent EP1572962. AB055780 - Homo sapiens mRNA for ribosomal protein S29, partial cds. JD433010 - Sequence 414034 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03010 - Ribosome
Reactome (by CSHL, EBI, and GO)
Protein P62273 (Reactome details) participates in the following event(s):
R-HSA-72676 eIF3 and eIF1A bind to the 40S subunit R-HSA-72673 Release of 40S and 60S subunits from the 80S ribosome R-HSA-72672 The 60S subunit joins the translation initiation complex R-HSA-72619 eIF2:GTP is hydrolyzed, eIFs are released R-HSA-72691 Formation of the 43S pre-initiation complex R-HSA-156808 Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation R-HSA-157849 Formation of translation initiation complexes containing mRNA that does not circularize R-HSA-72671 eIF5B:GTP is hydrolyzed and released R-HSA-156907 Aminoacyl-tRNA binds to the ribosome at the A-site R-HSA-2408529 Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome R-HSA-141691 GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex R-HSA-156915 Translocation of ribosome by 3 bases in the 3' direction R-HSA-141671 Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex R-HSA-156912 Peptide transfer from P-site tRNA to the A-site tRNA R-HSA-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex R-HSA-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex R-HSA-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) R-HSA-156923 Hydrolysis of eEF1A:GTP R-HSA-72621 Ribosomal scanning R-HSA-72697 Start codon recognition R-HSA-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA R-HSA-5333615 80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC R-HSA-141673 GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex R-HSA-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) R-HSA-1799329 Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein R-HSA-1799330 The SRP receptor binds the SRP:nascent peptide:ribosome complex R-HSA-1799326 Signal-containing nascent peptide translocates to endoplasmic reticulum R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72649 Translation initiation complex formation R-HSA-72737 Cap-dependent Translation Initiation R-HSA-8868773 rRNA processing in the nucleus and cytosol R-HSA-156902 Peptide chain elongation R-HSA-2408557 Selenocysteine synthesis R-HSA-72764 Eukaryotic Translation Termination R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-72766 Translation R-HSA-376176 Signaling by ROBO receptors R-HSA-192823 Viral mRNA Translation R-HSA-72702 Ribosomal scanning and start codon recognition R-HSA-156827 L13a-mediated translation R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72613 Eukaryotic Translation Initiation R-HSA-72312 rRNA processing R-HSA-156842 Eukaryotic Translation Elongation R-HSA-2408522 Selenoamino acid metabolism R-HSA-927802 Nonsense-Mediated Decay (NMD) R-HSA-392499 Metabolism of proteins R-HSA-422475 Axon guidance R-HSA-168273 Influenza Viral RNA Transcription and Replication R-HSA-8953854 Metabolism of RNA R-HSA-71291 Metabolism of nitrogenous molecules R-HSA-1266738 Developmental Biology R-HSA-168255 Influenza Life Cycle R-HSA-1430728 Metabolism R-HSA-168254 Influenza Infection R-HSA-5663205 Infectious disease R-HSA-1643685 Disease