Human Gene ARF6 (ENST00000298316.7) from GENCODE V44
Description: Homo sapiens ADP ribosylation factor 6 (ARF6), mRNA. (from RefSeq NM_001663) RefSeq Summary (NM_001663): This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000298316.7 Gencode Gene: ENSG00000165527.8 Transcript (Including UTRs) Position: hg38 chr14:49,893,082-49,897,054 Size: 3,973 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr14:49,893,737-49,894,264 Size: 528 Coding Exon Count: 1
ID:ARF6_HUMAN DESCRIPTION: RecName: Full=ADP-ribosylation factor 6; FUNCTION: GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension. SUBUNIT: Interacts with ARHGAP21, ASAP2, HERC1, PIP5K1C and UACA. Interacts with NCS1/FREQ at the plasma membrane. Interacts with RAB11FIP3 and RAB11FIP4. Interacts with USP6 (via Rab-GAP TBC domain). Interacts with ECM29. Interacts with TBC1D24. INTERACTION: P53365:ARFIP2; NbExp=4; IntAct=EBI-638181, EBI-638194; P21283:ATP6V1C1; NbExp=4; IntAct=EBI-638181, EBI-988663; SUBCELLULAR LOCATION: Golgi apparatus. Cell membrane; Lipid- anchor. Endosome membrane; Lipid-anchor. Cell membrane. Cell projection, filopodium membrane; Lipid-anchor. Note=Recruited to the cell membrane in association with CYTH2 and ARL4C. TISSUE SPECIFICITY: Ubiquitous, with higher levels in heart, substantia nigra, and kidney. SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P62330
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001889 liver development GO:0007049 cell cycle GO:0007155 cell adhesion GO:0007399 nervous system development GO:0015031 protein transport GO:0016192 vesicle-mediated transport GO:0030154 cell differentiation GO:0030838 positive regulation of actin filament polymerization GO:0030866 cortical actin cytoskeleton organization GO:0032456 endocytic recycling GO:0033028 myeloid cell apoptotic process GO:0034394 protein localization to cell surface GO:0035020 regulation of Rac protein signal transduction GO:0036010 protein localization to endosome GO:0048261 negative regulation of receptor-mediated endocytosis GO:0051301 cell division GO:0051489 regulation of filopodium assembly GO:0060998 regulation of dendritic spine development GO:0090162 establishment of epithelial cell polarity GO:0097178 ruffle assembly GO:0097284 hepatocyte apoptotic process GO:1903078 positive regulation of protein localization to plasma membrane GO:2000009 negative regulation of protein localization to cell surface GO:2000171 negative regulation of dendrite development
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