Human Gene TMX1 (ENST00000457354.7) from GENCODE V44
Description: Homo sapiens thioredoxin related transmembrane protein 1 (TMX1), mRNA. (from RefSeq NM_030755) RefSeq Summary (NM_030755): This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides. [provided by RefSeq, Jan 2017]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000457354.7 Gencode Gene: ENSG00000139921.13 Transcript (Including UTRs) Position: hg38 chr14:51,240,247-51,257,655 Size: 17,409 Total Exon Count: 8 Strand: + Coding Region Position: hg38 chr14:51,240,293-51,254,519 Size: 14,227 Coding Exon Count: 8
ID:TMX1_HUMAN DESCRIPTION: RecName: Full=Thioredoxin-related transmembrane protein 1; AltName: Full=Thioredoxin domain-containing protein 1; AltName: Full=Transmembrane Trx-related protein; Flags: Precursor; FUNCTION: May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). Endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Note=Predominantly found in the endoplasmic reticulum. TISSUE SPECIFICITY: Ubiquitous. Highly expressed in kidney, liver, placenta and lung. SIMILARITY: Contains 1 thioredoxin domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H3N1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.