Human Gene CALM1 (ENST00000356978.9) from GENCODE V44
Description: Homo sapiens calmodulin 1 (CALM1), transcript variant 2, mRNA. (from RefSeq NM_006888) RefSeq Summary (NM_006888): This gene encodes one of three calmodulin proteins which are members of the EF-hand calcium-binding protein family. Calcium-induced activation of calmodulin regulates and modulates the function of cardiac ion channels. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.A missense mutation in the CALM1 gene has been associated with ventricular tachycardia.[provided by RefSeq, May 2020]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000356978.9 Gencode Gene: ENSG00000198668.14 Transcript (Including UTRs) Position: hg38 chr14:90,397,029-90,408,268 Size: 11,240 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr14:90,397,231-90,404,717 Size: 7,487 Coding Exon Count: 6
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCarta from NCI Cancer Genome Anatomy Project h_At1rPathway - Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling h_fMLPpathway - fMLP induced chemokine gene expression in HMC-1 cells h_gpcrPathway - Signaling Pathway from G-Protein Families h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart) h_pyk2Pathway - Links between Pyk2 and Map Kinases h_Ccr5Pathway - Pertussis toxin-insensitive CCR5 Signaling in Macrophage h_gcrPathway - Corticosteroids and cardioprotection h_no1Pathway - Actions of Nitric Oxide in the Heart h_mef2dPathway - Role of MEF2D in T-cell Apoptosis h_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathway h_nos1Pathway - Nitric Oxide Signaling Pathway h_pgc1aPathway - Regulation of PGC-1a h_vipPathway - Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells h_tcrPathway - T Cell Receptor Signaling Pathway h_bcrPathway - BCR Signaling Pathway h_calcineurinPathway - Effects of calcineurin in Keratinocyte Differentiation h_ndkDynaminPathway - Endocytotic role of NDK, Phosphins and Dynamin h_CaCaMPathway - Ca++/ Calmodulin-dependent Protein Kinase Activation h_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cells h_hdacPathway - Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)