Human Gene AK7 (ENST00000267584.9) from GENCODE V44
Description: Homo sapiens adenylate kinase 7 (AK7), transcript variant 1, mRNA. (from RefSeq NM_152327) RefSeq Summary (NM_152327): This gene encodes a member of the adenylate kinase family of enzymes. The encoded enzyme is a phosphotransferase that catalyzes the reversible phosphorylation of adenine nucleotides. This enzyme plays a role in energy homeostasis of the cell. Alternative splicing results in multiple transcript variants. Mutations in the mouse gene are associated with primary ciliary dyskinesia. [provided by RefSeq, Apr 2017]. Gencode Transcript: ENST00000267584.9 Gencode Gene: ENSG00000140057.9 Transcript (Including UTRs) Position: hg38 chr14:96,392,128-96,489,427 Size: 97,300 Total Exon Count: 18 Strand: + Coding Region Position: hg38 chr14:96,392,155-96,488,343 Size: 96,189 Coding Exon Count: 18
ID:KAD7_HUMAN DESCRIPTION: RecName: Full=Adenylate kinase 7; EC=2.7.4.3; FUNCTION: Adenylate kinase involved in maintaining ciliary structure and function (By similarity). Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. CATALYTIC ACTIVITY: ATP + AMP = 2 ADP. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=1.0 uM for AMP; KM=28 uM for dAMP; KM=1.2 uM for CMP; Vmax=1130 pmol/min/ug enzyme with AMP as substrate; Vmax=860 pmol/min/ug enzyme with dAMP as substrate; Vmax=150 pmol/min/ug enzyme with CMP as substrate; SUBCELLULAR LOCATION: Cytoplasm, cytosol. SIMILARITY: In the central section; belongs to the adenylate kinase family. SIMILARITY: In the C-terminal section; belongs to the dpy-30 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96M32
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00230 - Purine metabolism hsa01100 - Metabolic pathways
BioCyc Knowledge Library PWY-7219 - adenosine ribonucleotides de novo biosynthesis PWY-841 - purine nucleotides de novo biosynthesis PWY66-409 - superpathway of purine nucleotide salvage
Reactome (by CSHL, EBI, and GO)
Protein Q96M32 (Reactome details) participates in the following event(s):
R-HSA-110137 (d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP R-HSA-110138 AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs R-HSA-499943 Interconversion of nucleotide di- and triphosphates R-HSA-15869 Metabolism of nucleotides R-HSA-1430728 Metabolism