Human Gene CCNK (ENST00000389879.9) from GENCODE V44
Description: Homo sapiens cyclin K (CCNK), mRNA. (from RefSeq NM_001099402) RefSeq Summary (NM_001099402): The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000389879.9 Gencode Gene: ENSG00000090061.17 Transcript (Including UTRs) Position: hg38 chr14:99,481,409-99,512,440 Size: 31,032 Total Exon Count: 11 Strand: + Coding Region Position: hg38 chr14:99,492,678-99,510,782 Size: 18,105 Coding Exon Count: 10
ID:CCNK_HUMAN DESCRIPTION: RecName: Full=Cyclin-K; FUNCTION: May play a role in transcriptional regulation. In vitro, is associated with a kinase activity toward both RNA polymerase II C-terminal domain and CDK2 (CAK). SUBUNIT: Part of a cyclin-kinase pair in the RNA polymerase II holoenzyme. Binds to CDK9. INTERACTION: P54253:ATXN1; NbExp=2; IntAct=EBI-739806, EBI-930964; TISSUE SPECIFICITY: Ubiquitously expressed. Highest levels in testis. SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily. WEB RESOURCE: Name=NIEHS SNPs; URL="http://egp.gs.washington.edu/data/ccnk/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75909
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004674 protein serine/threonine kinase activity GO:0004693 cyclin-dependent protein serine/threonine kinase activity GO:0005515 protein binding GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity GO:0019901 protein kinase binding
Biological Process: GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006368 transcription elongation from RNA polymerase II promoter GO:0006468 protein phosphorylation GO:0006974 cellular response to DNA damage stimulus GO:0007049 cell cycle GO:0042795 snRNA transcription from RNA polymerase II promoter GO:0044828 negative regulation by host of viral genome replication GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0051301 cell division GO:0071157 negative regulation of cell cycle arrest GO:2001165 positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
DQ893538 - Synthetic construct clone IMAGE:100006168; FLH164538.01X; RZPDo839H04162D cyclin K (CCNK) gene, encodes complete protein. EU176485 - Synthetic construct Homo sapiens clone IMAGE:100011337; FLH164537.01L; RZPDo839F02253D cyclin K (CCNK) gene, encodes complete protein. BC015935 - Homo sapiens cyclin K, mRNA (cDNA clone MGC:9113 IMAGE:3907416), complete cds. AK311075 - Homo sapiens cDNA, FLJ18117. AF060515 - Homo sapiens cyclin K (CPR4) mRNA, complete cds. CU677519 - Synthetic construct Homo sapiens gateway clone IMAGE:100017077 5' read CCNK mRNA. BT006950 - Homo sapiens cyclin K mRNA, complete cds. KJ904610 - Synthetic construct Homo sapiens clone ccsbBroadEn_14004 CCNK gene, encodes complete protein. AB209373 - Homo sapiens premature mRNA for CS0DA006YC23 variant. BX247958 - human full-length cDNA clone CS0DA006YC23 of Neuroblastoma of Homo sapiens (human). AK000799 - Homo sapiens cDNA FLJ20792 fis, clone COL01292. JD304789 - Sequence 285813 from Patent EP1572962. JD214834 - Sequence 195858 from Patent EP1572962. JD113597 - Sequence 94621 from Patent EP1572962. JD415690 - Sequence 396714 from Patent EP1572962. JD062739 - Sequence 43763 from Patent EP1572962. JD244291 - Sequence 225315 from Patent EP1572962. JD357890 - Sequence 338914 from Patent EP1572962. JD087193 - Sequence 68217 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O75909 (Reactome details) participates in the following event(s):
R-HSA-6797090 CCNK binds CDK12 R-HSA-6797100 CCNK binds CDK13 R-HSA-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes R-HSA-112430 Formation of P-TEFb complex R-HSA-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes R-HSA-112381 Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex R-HSA-167084 Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex R-HSA-6810234 General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene R-HSA-113429 Elongating transcript encounters a lesion in the template R-HSA-112379 Recruitment of elongation factors to form elongation complex R-HSA-113411 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing R-HSA-113412 Pol II elongation complex moves on the template as transcript elongates R-HSA-113414 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest R-HSA-112385 Addition of nucleotides leads to transcript elongation R-HSA-112392 Resumption of elongation after recovery from pausing R-HSA-113413 TFIIS-mediated recovery of elongation from arrest R-HSA-112395 Abortive termination of elongation after arrest R-HSA-112396 Separation of elongating transcript from template R-HSA-167077 Recruitment of elongation factors to form HIV-1 elongation complex R-HSA-167282 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing R-HSA-167284 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest R-HSA-167288 TFIIS-mediated recovery of HIV-1 elongation from arrest R-HSA-167292 Resumption of elongation of HIV-1 transcript after recovery from pausing R-HSA-167481 Abortive termination of HIV-1 elongation after arrest R-HSA-6810238 RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) R-HSA-6810235 RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain R-HSA-6810233 CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter R-HSA-6814885 CBCAP complex binds 7-methylguanosine cap of snRNA R-HSA-2176475 Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-112382 Formation of RNA Pol II elongation complex R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat R-HSA-6807505 RNA polymerase II transcribes snRNA genes R-HSA-73857 RNA Polymerase II Transcription R-HSA-212436 Generic Transcription Pathway R-HSA-75955 RNA Polymerase II Transcription Elongation R-HSA-167290 Pausing and recovery of HIV elongation R-HSA-167287 HIV elongation arrest and recovery R-HSA-167172 Transcription of the HIV genome R-HSA-74160 Gene expression (Transcription) R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-162599 Late Phase of HIV Life Cycle R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-162587 HIV Life Cycle R-HSA-170834 Signaling by TGF-beta Receptor Complex R-HSA-162906 HIV Infection R-HSA-9006936 Signaling by TGF-beta family members R-HSA-5663205 Infectious disease R-HSA-162582 Signal Transduction R-HSA-1643685 Disease
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