Human Gene WDR25 (ENST00000335290.10) from GENCODE V44
Description: Homo sapiens WD repeat domain 25 (WDR25), transcript variant 1, mRNA. (from RefSeq NM_024515) RefSeq Summary (NM_024515): This gene encodes a protein containing 7 WD repeats. WD repeats are approximately 30 to 40-amino acid domains containing several conserved residues, typically having a Tryptophan-Aspartic acid dipeptide (WD) at the C-terminal end. WD domains are involved in protein-protein interactions in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]. Gencode Transcript: ENST00000335290.10 Gencode Gene: ENSG00000176473.14 Transcript (Including UTRs) Position: hg38 chr14:100,376,494-100,530,303 Size: 153,810 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr14:100,380,925-100,530,041 Size: 149,117 Coding Exon Count: 6
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q64LD2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.