Human Gene EIF5 (ENST00000216554.8) from GENCODE V44
Description: Homo sapiens eukaryotic translation initiation factor 5 (EIF5), transcript variant 1, mRNA. (from RefSeq NM_001969) RefSeq Summary (NM_001969): Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si et al., 1996 [PubMed 8663286]).[supplied by OMIM, May 2010]. Gencode Transcript: ENST00000216554.8 Gencode Gene: ENSG00000100664.11 Transcript (Including UTRs) Position: hg38 chr14:103,334,237-103,345,025 Size: 10,789 Total Exon Count: 12 Strand: + Coding Region Position: hg38 chr14:103,335,861-103,341,052 Size: 5,192 Coding Exon Count: 10
ID:IF5_HUMAN DESCRIPTION: RecName: Full=Eukaryotic translation initiation factor 5; Short=eIF-5; FUNCTION: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]). SIMILARITY: Belongs to the eIF-2-beta/eIF-5 family. SIMILARITY: Contains 1 W2 domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P55010
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
