Human Gene NSMCE3 (ENST00000332303.6) from GENCODE V44
Description: Homo sapiens NSE3 homolog, SMC5-SMC6 complex component (NSMCE3), mRNA. (from RefSeq NM_138704) RefSeq Summary (NM_138704): The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE superfamily. This is an intronless gene. [provided by RefSeq, May 2011]. Gencode Transcript: ENST00000332303.6 Gencode Gene: ENSG00000185115.6 Transcript (Including UTRs) Position: hg38 chr15:29,264,989-29,269,822 Size: 4,834 Total Exon Count: 1 Strand: - Coding Region Position: hg38 chr15:29,268,791-29,269,705 Size: 915 Coding Exon Count: 1
ID:MAGG1_HUMAN DESCRIPTION: RecName: Full=Melanoma-associated antigen G1; AltName: Full=Hepatocellular carcinoma-associated protein 4; AltName: Full=MAGE-G1 antigen; AltName: Full=Necdin-like protein 2; FUNCTION: Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest. SUBUNIT: Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NDNL2. NSMCE1, NSMCE4A or EID3 and NDNL2 probably form a subcomplex that bridges the head domains of the SMC5:SMC6 heterodimer. Interacts with PJA1. Binds the C-terminus of E2F1 and NGFR (By similarity). INTERACTION: Q8N140:EID3; NbExp=4; IntAct=EBI-2557356, EBI-744483; Q8WV22:NSMCE1; NbExp=15; IntAct=EBI-2557356, EBI-2557372; Q9NXX6:NSMCE4A; NbExp=3; IntAct=EBI-2557356, EBI-2557393; Q8NG27:PJA1; NbExp=2; IntAct=EBI-2557356, EBI-714606; SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus. Chromosome, telomere (Probable). TISSUE SPECIFICITY: Ubiquitous. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 1 MAGE domain. SEQUENCE CAUTION: Sequence=BAB84964.1; Type=Frameshift; Positions=290;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96MG7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0046983 protein dimerization activity
Biological Process: GO:0006281 DNA repair GO:0006310 DNA recombination GO:0006974 cellular response to DNA damage stimulus GO:0031398 positive regulation of protein ubiquitination GO:0034644 cellular response to UV GO:0040008 regulation of growth GO:0071478 cellular response to radiation GO:0072711 cellular response to hydroxyurea