Human Gene GOLGA8A (ENST00000359187.4) Description and Page Index
  Description: Homo sapiens golgin A8 family member A (GOLGA8A), transcript variant 1, mRNA. (from RefSeq NM_181077)
RefSeq Summary (NM_181077): The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked, flattened membrane sacs referred to as cisternae. Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The golgins constitute a family of proteins which are localized to the Golgi. This gene encodes a golgin which structurally resembles its family member GOLGA2, suggesting that they may share a similar function. There are many similar copies of this gene on chromosome 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.253585.1, BC093673.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##
Gencode Transcript: ENST00000359187.4
Gencode Gene: ENSG00000175265.17
Transcript (Including UTRs)
   Position: hg38 chr15:34,381,411-34,389,756 Size: 8,346 Total Exon Count: 16 Strand: -
Coding Region
   Position: hg38 chr15:34,381,411-34,389,691 Size: 8,281 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr15:34,381,411-34,389,756)mRNA (may differ from genome)Protein (603 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGIneXtProtOMIMPubMedStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Golgin subfamily A member 8A; AltName: Full=88 kDa Golgi matrix protein; Short=GM88; AltName: Full=GM88 autoantigen;
FUNCTION: May be involved in maintaining Golgi structure (By similarity).
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Peripheral membrane protein (By similarity).
SIMILARITY: Belongs to the GOLGA8 family.
CAUTION: A family of highly similar proteins (GOLGA8A, GOLGA8B, GOLGA8C, GOLGA8D, GOLGA8E, GOLGA8F, GOLGA8G) are encoded by a repeated region on chromosome 15q11-15q13. Our sequences are in agreement with HGNC nomenclature.
SEQUENCE CAUTION: Sequence=AAI44610.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI50330.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAI52411.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAA74878.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAH18214.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 86.36 RPKM in Brain - Cerebellum
Total median expression: 1223.09 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -14.5065-0.223 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024858 - Golgin_A

ModBase Predicted Comparative 3D Structure on A7E2F4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016020 membrane
GO:0032580 Golgi cisterna membrane

-  Descriptions from all associated GenBank mRNAs
  KJ898434 - Synthetic construct Homo sapiens clone ccsbBroadEn_07828 GOLGA8A gene, encodes complete protein.
BX648160 - Homo sapiens mRNA; cDNA DKFZp686I2332 (from clone DKFZp686I2332).
AL137686 - Homo sapiens mRNA; cDNA DKFZp434J052 (from clone DKFZp434J052).
BC150329 - Homo sapiens golgi autoantigen, golgin subfamily a, 8A, mRNA (cDNA clone IMAGE:8860496), partial cds.
BC152410 - Homo sapiens golgi autoantigen, golgin subfamily a, 8A, mRNA (cDNA clone IMAGE:8862513), partial cds.
BX648575 - Homo sapiens mRNA; cDNA DKFZp686N015 (from clone DKFZp686N015).
AB020662 - Homo sapiens mRNA for KIAA0855 protein, partial cds.
AF204231 - Homo sapiens 88-kDa Golgi protein (GM88) mRNA, complete cds.
AL117569 - Homo sapiens mRNA; cDNA DKFZp564E0216 (from clone DKFZp564E0216).
BC144609 - Homo sapiens golgi autoantigen, golgin subfamily a, 8A, mRNA (cDNA clone MGC:178157 IMAGE:9053140), complete cds.
CR749361 - Homo sapiens mRNA; cDNA DKFZp779P0341 (from clone DKFZp779P0341).
AK097551 - Homo sapiens cDNA FLJ40232 fis, clone TESTI2023033, highly similar to Homo sapiens golgin 67 mRNA.
AF163441 - Homo sapiens golgin 67 mRNA, complete cds.
BC093673 - Homo sapiens golgi autoantigen, golgin subfamily a, 8A, mRNA (cDNA clone MGC:120708 IMAGE:7939518), complete cds.
BC104800 - Homo sapiens golgi autoantigen, golgin subfamily a, 8A, mRNA (cDNA clone MGC:132460 IMAGE:8143803), complete cds.
BC143254 - Homo sapiens golgi autoantigen, golgin subfamily a, 8B, mRNA (cDNA clone MGC:176773 IMAGE:9051756), complete cds.
AB384017 - Synthetic construct DNA, clone: pF1KSDA0855, Homo sapiens GOLGA8A gene for golgin subfamily A member 8A/B, complete cds, without stop codon, in Flexi system.
DQ597116 - Homo sapiens piRNA piR-35182, complete sequence.
DQ581935 - Homo sapiens piRNA piR-32047, complete sequence.
DQ570015 - Homo sapiens piRNA piR-30127, complete sequence.
DQ573778 - Homo sapiens piRNA piR-41890, complete sequence.
JD205481 - Sequence 186505 from Patent EP1572962.
DQ573481 - Homo sapiens piRNA piR-41593, complete sequence.
DQ586339 - Homo sapiens piRNA piR-53451, complete sequence.
BC032774 - Homo sapiens golgi autoantigen, golgin subfamily a, 8A, mRNA (cDNA clone IMAGE:4431785), partial cds.
JD085536 - Sequence 66560 from Patent EP1572962.
AK123221 - Homo sapiens cDNA FLJ41227 fis, clone BRAMY2030545.
JD123107 - Sequence 104131 from Patent EP1572962.
DQ590489 - Homo sapiens piRNA piR-57601, complete sequence.
JD121250 - Sequence 102274 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A7E2F4, A7MCY9, B7ZMK5, GOG8A_HUMAN, NM_181077, O94937, Q52M46, Q68DK6, Q9NZG8, Q9NZW0, Q9NZW3, uc001zii.1, uc001zii.2, uc001zii.3, uc001zii.4
UCSC ID: uc001zii.4
RefSeq Accession: NM_181077
Protein: A7E2F4 (aka GOG8A_HUMAN)
CCDS: CCDS10038.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.