Description: Homo sapiens Meis homeobox 2 (MEIS2), transcript variant a, mRNA. (from RefSeq NM_170677) RefSeq Summary (NM_170677): This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000424352.6 Gencode Gene: ENSG00000134138.20 Transcript (Including UTRs) Position: hg38 chr15:36,891,850-37,100,530 Size: 208,681 Total Exon Count: 13 Strand: - Coding Region Position: hg38 chr15:36,894,754-37,099,466 Size: 204,713 Coding Exon Count: 12
ID:MEIS2_HUMAN DESCRIPTION: RecName: Full=Homeobox protein Meis2; AltName: Full=Meis1-related protein 1; SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Expressed in various tissues. Expressed at high level in the lymphoid organs of hematopoietic tissues. Also expressed in some regions of the brain, such as the putamen. SIMILARITY: Belongs to the TALE/MEIS homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14770
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003712 transcription cofactor activity GO:0003714 transcription corepressor activity GO:0005515 protein binding GO:0008134 transcription factor binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001654 eye development GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0008542 visual learning GO:0009612 response to mechanical stimulus GO:0031016 pancreas development GO:0045638 negative regulation of myeloid cell differentiation GO:0045931 positive regulation of mitotic cell cycle GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0070848 response to growth factor