Human Gene MEIS2 (ENST00000424352.6)
  Description: Homo sapiens Meis homeobox 2 (MEIS2), transcript variant a, mRNA. (from RefSeq NM_170677)
RefSeq Summary (NM_170677): This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000424352.6
Gencode Gene: ENSG00000134138.20
Transcript (Including UTRs)
   Position: hg38 chr15:36,891,850-37,100,530 Size: 208,681 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg38 chr15:36,894,754-37,099,466 Size: 204,713 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:36,891,850-37,100,530)mRNA (may differ from genome)Protein (401 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGIneXtProtOMIMPubMedUniProtKB
Wikipedia

-  Comments and Description Text from UniProtKB
  ID: MEIS2_HUMAN
DESCRIPTION: RecName: Full=Homeobox protein Meis2; AltName: Full=Meis1-related protein 1;
SUBCELLULAR LOCATION: Nucleus (Probable).
TISSUE SPECIFICITY: Expressed in various tissues. Expressed at high level in the lymphoid organs of hematopoietic tissues. Also expressed in some regions of the brain, such as the putamen.
SIMILARITY: Belongs to the TALE/MEIS homeobox family.
SIMILARITY: Contains 1 homeobox DNA-binding domain.

-  MalaCards Disease Associations
  MalaCards Gene Search: MEIS2
Diseases sorted by gene-association score: cleft palate, cardiac defects, and mental retardation* (919), chromosome 15q14 deletion syndrome* (18), learning disability (7), spastic paraplegia 11, autosomal recessive (6), intellectual disability (2), cleft lip/palate (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.57 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 278.97 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -357.301064-0.336 Picture PostScript Text
3' UTR -143.20647-0.221 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008422 - Homeobox_KN_domain
IPR001356 - Homeodomain
IPR009057 - Homeodomain-like

Pfam Domains:
PF05920 - Homeobox KN domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

3K2A
- X-ray MuPIT


ModBase Predicted Comparative 3D Structure on O14770
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003712 transcription cofactor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001654 eye development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007275 multicellular organism development
GO:0008542 visual learning
GO:0009612 response to mechanical stimulus
GO:0031016 pancreas development
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0070848 response to growth factor

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AF017418 - Homo sapiens homeobox protein MEIS2 (MEIS2) mRNA, partial cds.
AK226072 - Homo sapiens mRNA for homeobox protein Meis2 isoform c variant, clone: fk13183.
BC001516 - Homo sapiens Meis homeobox 2, mRNA (cDNA clone MGC:2820 IMAGE:2964406), complete cds.
BC001844 - Homo sapiens Meis homeobox 2, mRNA (cDNA clone MGC:4493 IMAGE:2964406), complete cds.
BC007202 - Homo sapiens Meis homeobox 2, mRNA (cDNA clone MGC:12955 IMAGE:2964406), complete cds.
BC050431 - Homo sapiens Meis homeobox 2, mRNA (cDNA clone MGC:54158 IMAGE:6066728), complete cds.
AF178948 - Homo sapiens TALE homeobox protein Meis2a mRNA, complete cds.
AF179896 - Homo sapiens TALE homeobox protein Meis2b mRNA, complete cds.
AF179897 - Homo sapiens TALE homeobox protein Meis2c mRNA, complete cds.
AF179898 - Homo sapiens TALE homeobox protein Meis2d mRNA, complete cds.
AF179899 - Homo sapiens TALE homeobox protein Meis2e mRNA, complete cds.
AK056038 - Homo sapiens cDNA FLJ31476 fis, clone NT2NE2001617, highly similar to HOMEOBOX PROTEIN MEIS2.
AK055936 - Homo sapiens cDNA FLJ31374 fis, clone NB9N42000430, highly similar to HOMEOBOX PROTEIN MEIS2.
AK056620 - Homo sapiens cDNA FLJ32058 fis, clone NTONG2001657, highly similar to Homo sapiens Meis1, myeloid ecotropic viral integration site 1 homolog 2 (mouse) (MEIS2), transcript variant h, mRNA.
AK056216 - Homo sapiens cDNA FLJ31654 fis, clone NT2RI2004230, highly similar to Homeobox protein Meis2.
AK300247 - Homo sapiens cDNA FLJ58324 complete cds, highly similar to Homeobox protein Meis2.
AK311546 - Homo sapiens cDNA, FLJ18588.
AK294411 - Homo sapiens cDNA FLJ55195 complete cds, highly similar to Homeobox protein Meis2.
KJ891604 - Synthetic construct Homo sapiens clone ccsbBroadEn_00998 MEIS2 gene, encodes complete protein.
EU446635 - Synthetic construct Homo sapiens clone IMAGE:100070192; IMAGE:100011844; FLH257292.01L Meis homeobox 2 (MEIS2) gene, encodes complete protein.
EU831824 - Synthetic construct Homo sapiens clone HAIB:100066853; DKFZo004A0122 Meis homeobox 2 protein (MEIS2) gene, encodes complete protein.
KJ891605 - Synthetic construct Homo sapiens clone ccsbBroadEn_00999 MEIS2 gene, encodes complete protein.
EU831754 - Synthetic construct Homo sapiens clone HAIB:100066783; DKFZo008A0821 Meis homeobox 2 protein (MEIS2) gene, encodes complete protein.
EU831831 - Synthetic construct Homo sapiens clone HAIB:100066860; DKFZo004A0822 Meis homeobox 2 protein (MEIS2) gene, encodes complete protein.
AB463111 - Synthetic construct DNA, clone: pF1KB4670, Homo sapiens MEIS2 gene for Meis homeobox 2, without stop codon, in Flexi system.
CU690674 - Synthetic construct Homo sapiens gateway clone IMAGE:100021476 5' read MEIS2 mRNA.
CU674744 - Synthetic construct Homo sapiens gateway clone IMAGE:100021893 5' read MEIS2 mRNA.
AK094531 - Homo sapiens cDNA FLJ37212 fis, clone BRALZ2008166.
AK001298 - Homo sapiens cDNA FLJ10436 fis, clone NT2RP1000574.
JD420628 - Sequence 401652 from Patent EP1572962.
JD278473 - Sequence 259497 from Patent EP1572962.
JD168633 - Sequence 149657 from Patent EP1572962.
JD344532 - Sequence 325556 from Patent EP1572962.
AY349358 - Homo sapiens unknown mRNA.
JD488969 - Sequence 469993 from Patent EP1572962.
JD452331 - Sequence 433355 from Patent EP1572962.
JD380694 - Sequence 361718 from Patent EP1572962.
JD288326 - Sequence 269350 from Patent EP1572962.
JD123132 - Sequence 104156 from Patent EP1572962.
JD043069 - Sequence 24093 from Patent EP1572962.
JD504741 - Sequence 485765 from Patent EP1572962.
JD235674 - Sequence 216698 from Patent EP1572962.
AK125465 - Homo sapiens cDNA FLJ43476 fis, clone OCBBF3000097, weakly similar to HOMEOBOX PROTEIN MEIS2.
LF212909 - JP 2014500723-A/20412: Polycomb-Associated Non-Coding RNAs.
MA448486 - JP 2018138019-A/20412: Polycomb-Associated Non-Coding RNAs.
JD242235 - Sequence 223259 from Patent EP1572962.
JD519147 - Sequence 500171 from Patent EP1572962.
JD091183 - Sequence 72207 from Patent EP1572962.
JD308811 - Sequence 289835 from Patent EP1572962.
JD468635 - Sequence 449659 from Patent EP1572962.
JD445051 - Sequence 426075 from Patent EP1572962.
JD178299 - Sequence 159323 from Patent EP1572962.
JD468634 - Sequence 449658 from Patent EP1572962.
JD540787 - Sequence 521811 from Patent EP1572962.
JD343892 - Sequence 324916 from Patent EP1572962.
JD340466 - Sequence 321490 from Patent EP1572962.
JD178537 - Sequence 159561 from Patent EP1572962.
JD178536 - Sequence 159560 from Patent EP1572962.
JD408171 - Sequence 389195 from Patent EP1572962.
JD178401 - Sequence 159425 from Patent EP1572962.
JD340032 - Sequence 321056 from Patent EP1572962.
JD434765 - Sequence 415789 from Patent EP1572962.
JD043443 - Sequence 24467 from Patent EP1572962.
JD445813 - Sequence 426837 from Patent EP1572962.
JD533523 - Sequence 514547 from Patent EP1572962.
JD442133 - Sequence 423157 from Patent EP1572962.
JD306943 - Sequence 287967 from Patent EP1572962.
JD095362 - Sequence 76386 from Patent EP1572962.
JD370438 - Sequence 351462 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NJI5, A8MWD5, B3KP98, B3KPQ6, ENST00000424352.1, ENST00000424352.2, ENST00000424352.3, ENST00000424352.4, ENST00000424352.5, MEIS2_HUMAN, MRG1, NM_170677, O14770, Q96DI2, Q96KI4, Q96KI5, Q9NRS1, Q9NRS2, Q9NRS3, uc001zjo.1, uc001zjo.2, uc001zjo.3, uc001zjo.4, uc001zjo.5
UCSC ID: ENST00000424352.6
RefSeq Accession: NM_170677
Protein: O14770 (aka MEIS2_HUMAN or MEI2_HUMAN)
CCDS: CCDS42014.1, CCDS45217.1, CCDS45218.1, CCDS45219.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.