Human Gene SLC30A4 (ENST00000261867.5) from GENCODE V44
Description: Homo sapiens solute carrier family 30 member 4 (SLC30A4), transcript variant 1, mRNA. (from RefSeq NM_013309) RefSeq Summary (NM_013309): Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]).[supplied by OMIM, Mar 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000261867.5 Gencode Gene: ENSG00000104154.7 Transcript (Including UTRs) Position: hg38 chr15:45,479,606-45,522,755 Size: 43,150 Total Exon Count: 8 Strand: - Coding Region Position: hg38 chr15:45,485,163-45,522,354 Size: 37,192 Coding Exon Count: 7
ID:ZNT4_HUMAN DESCRIPTION: RecName: Full=Zinc transporter 4; Short=ZnT-4; AltName: Full=Solute carrier family 30 member 4; FUNCTION: Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment. SUBCELLULAR LOCATION: Endosome membrane; Multi-pass membrane protein (Probable). DOMAIN: Contains a histidine-rich region which is a ligand for zinc and an aspartate-rich region which is a potential ligand for zinc (By similarity). SIMILARITY: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14863
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
