Human Gene FBXO22 (ENST00000308275.8) from GENCODE V44
Description: Homo sapiens F-box protein 22 (FBXO22), transcript variant 1, mRNA. (from RefSeq NM_147188) RefSeq Summary (NM_147188): This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]. Gencode Transcript: ENST00000308275.8 Gencode Gene: ENSG00000167196.14 Transcript (Including UTRs) Position: hg38 chr15:75,903,878-75,942,511 Size: 38,634 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr15:75,903,964-75,933,102 Size: 29,139 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NEZ5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000209 protein polyubiquitination GO:0006464 cellular protein modification process GO:0006511 ubiquitin-dependent protein catabolic process GO:0006913 nucleocytoplasmic transport GO:0009267 cellular response to starvation GO:0010830 regulation of myotube differentiation GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0043687 post-translational protein modification GO:0048742 regulation of skeletal muscle fiber development GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process