Human Gene CREBBP (ENST00000262367.10)
  Description: Homo sapiens CREB binding protein (CREBBP), transcript variant 1, mRNA. (from RefSeq NM_004380)
RefSeq Summary (NM_004380): This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009].
Gencode Transcript: ENST00000262367.10
Gencode Gene: ENSG00000005339.15
Transcript (Including UTRs)
   Position: hg38 chr16:3,725,054-3,880,713 Size: 155,660 Total Exon Count: 31 Strand: -
Coding Region
   Position: hg38 chr16:3,727,718-3,879,916 Size: 152,199 Coding Exon Count: 31 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesGeneReviewsMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:3,725,054-3,880,713)mRNA (may differ from genome)Protein (2442 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
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HPRDLynxMGIneXtProtOMIMPubMed
ReactomeUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: CBP_HUMAN
DESCRIPTION: RecName: Full=CREB-binding protein; EC=2.3.1.48;
FUNCTION: Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.
CATALYTIC ACTIVITY: Acetyl-CoA + [histone] = CoA + acetyl- [histone].
SUBUNIT: Found in a complex containing NCOA2; NCOA3; IKKA; IKKB and IKBKG. Probably part of a complex with HIF1A and EP300. Interacts with GATA1; the interaction results in acetylation and enhancement of transcriptional activity of GATA1. Interacts with MAF AND ZCCHC12. Interacts with DAXX; the interaction is dependent on CBP sumoylation and results in suppression of the transcriptional activiy via recruitment of HDAC2 to DAAX (By similarity). Interacts with phosphorylated CREB1. Interacts with CITED4 (C-terminal region). Interacts (via the TAZ-type 1 domain) with HIF1A. Interacts with SRCAP, CARM1, ELF3, MLLT7/FOXO4, N4BP2, NCOA1, NCOA3, NCOA6, PCAF, DDX5, DDX17, PELP1, PML, SMAD1, SMAD2, SMAD3, SPIB and TRERF1. Interacts with HTLV-1 Tax and p30II. Interacts with HIV-1 Tat. Interacts with KLF1; the interaction results in acetylation of KLF1 and enhancement of its transcriptional activity. Interacts with MTDH. Interacts with NFATC4. Interacts with MAFG; the interaction acetylates MAFG in the basic region and stimulates NFE2 transcriptional activity through increasing its DNA-binding activity. Interacts with IRF2; the interaction acetylates IRF2 and regulates its activity on the H4 promoter. Interacts (via N-terminus) with SS18L1/CREST (via C- terminus). Interacts with MECOM. Interacts with CITED1 (via C- terminus). Interacts with FOXO1; the interaction acetylates FOXO1 and inhibits its transcriptional activity.
INTERACTION: P10275:AR; NbExp=2; IntAct=EBI-81215, EBI-608057; Q9UER7:DAXX; NbExp=2; IntAct=EBI-81215, EBI-77321; Q12778:FOXO1; NbExp=2; IntAct=EBI-81215, EBI-1108782; P48551:IFNAR2; NbExp=4; IntAct=EBI-81215, EBI-958408; Q14653:IRF3; NbExp=3; IntAct=EBI-81215, EBI-2650369; Q92831:KAT2B; NbExp=3; IntAct=EBI-81215, EBI-477430; Q86UE4:MTDH; NbExp=2; IntAct=EBI-81215, EBI-1046588; P55209:NAP1L1; NbExp=3; IntAct=EBI-81215, EBI-356392; Q14686:NCOA6; NbExp=2; IntAct=EBI-81215, EBI-78670; Q04206:RELA; NbExp=3; IntAct=EBI-81215, EBI-73886; P04637:TP53; NbExp=6; IntAct=EBI-81215, EBI-366083;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus.
DOMAIN: The KIX domain mediates binding to HIV-1 Tat.
PTM: Methylation of the KIX domain by CARM1 blocks association with CREB. This results in the blockade of CREB signaling, and in activation of apoptotic response (By similarity).
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated by CHUK/IKKA at Ser-1382 and Ser-1386; these phosphorylations promote cell growth by switching the binding preference of CREBBP from TP53 to NF-kappa-B.
PTM: Sumoylation negatively regulates transcriptional activity via the recruitment of DAAX (By similarity).
DISEASE: Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription.
DISEASE: Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:180849]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.
SIMILARITY: Contains 1 bromo domain.
SIMILARITY: Contains 1 KIX domain.
SIMILARITY: Contains 2 TAZ-type zinc fingers.
SIMILARITY: Contains 1 ZZ-type zinc finger.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CBPID42.html";
WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CREBBP";
WEB RESOURCE: Name=Wikipedia; Note=P300/CBP entry; URL="http://en.wikipedia.org/wiki/P300/CBP";

-  MalaCards Disease Associations
  MalaCards Gene Search: CREBBP
Diseases sorted by gene-association score: rubinstein-taybi syndrome 1* (1581), chromosome 16p13.3 deletion syndrome, proximal* (456), acute myeloid leukemia with t(8;16)(p11;p13) translocation* (261), crebbp-related rubinstein-taybi syndrome* (100), neonatal leukemia (16), floating-harbor syndrome (13), acute monocytic leukemia (12), huntington disease (10), acute leukemia (10), retroperitoneal sarcoma (9), human t-cell leukemia virus type 1 (9), myeloid leukemia (7), leukemia (7), hiv-1 (6), retroperitoneum carcinoma (6), human t-cell leukemia virus type 2 (5), hypoxia (5), acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) (5), kaposi sarcoma (4), prostate cancer (2), intellectual disability (2), leukemia, acute myeloid (0), amyotrophic lateral sclerosis 1 (0)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.55 RPKM in Uterus
Total median expression: 566.38 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -521.90797-0.655 Picture PostScript Text
3' UTR -833.502664-0.313 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001487 - Bromodomain
IPR018359 - Bromodomain_CS
IPR010303 - DUF902_CREBbp
IPR013178 - Histone_H3-K56_AcTrfase_RTT109
IPR003101 - KIX
IPR009110 - Nuc_rcpt_coact
IPR014744 - Nuc_rcpt_coact_CREBbp
IPR000197 - Znf_TAZ
IPR000433 - Znf_ZZ

Pfam Domains:
PF00439 - Bromodomain
PF09030 - Creb binding
PF06001 - Domain of Unknown Function (DUF902)
PF08214 - Histone acetylation protein
PF02172 - KIX domain
PF02135 - TAZ zinc finger
PF00569 - Zinc finger, ZZ type

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1JSP
- NMR MuPIT

1LIQ
- NMR

1WO3
- NMR
To conserve bandwidth, only the images from the first 3 structures are shown.
1WO4 - NMR 1WO5 - NMR 1WO6 - NMR
1WO7 - NMR 1ZOQ - X-ray MuPIT 2D82 - NMR MuPIT
2KJE - NMR MuPIT 2KWF - NMR MuPIT 2L84 - NMR MuPIT
2L85 - NMR MuPIT 2RNY - NMR MuPIT 3DWY - X-ray MuPIT
3P1C - X-ray MuPIT 3P1D - X-ray MuPIT 3P1E - X-ray MuPIT
3P1F - X-ray MuPIT 3SVH - X-ray MuPIT 4A9K - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q92793
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001085 RNA polymerase II transcription factor binding
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding
GO:0002039 p53 binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003712 transcription cofactor activity
GO:0003713 transcription coactivator activity
GO:0004402 histone acetyltransferase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0016407 acetyltransferase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0034212 peptide N-acetyltransferase activity
GO:0043426 MRF binding
GO:0046872 metal ion binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001666 response to hypoxia
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006473 protein acetylation
GO:0007165 signal transduction
GO:0007219 Notch signaling pathway
GO:0007221 positive regulation of transcription of Notch receptor target
GO:0008589 regulation of smoothened signaling pathway
GO:0016032 viral process
GO:0016573 histone acetylation
GO:0018076 N-terminal peptidyl-lysine acetylation
GO:0019216 regulation of lipid metabolic process
GO:0031648 protein destabilization
GO:0032481 positive regulation of type I interferon production
GO:0034644 cellular response to UV
GO:0042592 homeostatic process
GO:0042733 embryonic digit morphogenesis
GO:0042981 regulation of apoptotic process
GO:0045637 regulation of myeloid cell differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048511 rhythmic process
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0065003 macromolecular complex assembly
GO:1900034 regulation of cellular response to heat
GO:1904837 beta-catenin-TCF complex assembly

Cellular Component:
GO:0000123 histone acetyltransferase complex
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016604 nuclear body


-  Descriptions from all associated GenBank mRNAs
  U47741 - Human CREB-binding protein (CBP) mRNA, complete cds.
AB210043 - Homo sapiens mRNA for CREBBP variant protein, clone: pf01047.
U85962 - Homo sapiens CREB-binding protein mRNA, complete cds.
AB527452 - Synthetic construct DNA, clone: pF1KB0067, Homo sapiens CREBBP gene for CREB binding protein, without stop codon, in Flexi system.
AJ251844 - Homo sapiens partial mRNA for MOZ/CBP chimeric transcript type II.
AJ251843 - Homo sapiens partial mRNA for MOZ/CBP chimeric transcript type I.
BC036486 - Homo sapiens CREB binding protein, mRNA (cDNA clone IMAGE:5261283), partial cds.
JD303805 - Sequence 284829 from Patent EP1572962.
U89355 - Homo sapiens clone cRT16 CREB-binding protein mRNA, partial cds.
JD095595 - Sequence 76619 from Patent EP1572962.
JD298801 - Sequence 279825 from Patent EP1572962.
JD436000 - Sequence 417024 from Patent EP1572962.
JD314452 - Sequence 295476 from Patent EP1572962.
JD469673 - Sequence 450697 from Patent EP1572962.
JD562580 - Sequence 543604 from Patent EP1572962.
JD183741 - Sequence 164765 from Patent EP1572962.
U89354 - Homo sapiens clone cRT0 CREB-binding protein mRNA, partial cds.
JD137934 - Sequence 118958 from Patent EP1572962.
JD297294 - Sequence 278318 from Patent EP1572962.
JD100174 - Sequence 81198 from Patent EP1572962.
JD110986 - Sequence 92010 from Patent EP1572962.
AK124320 - Homo sapiens cDNA FLJ42329 fis, clone TRACH3000558, highly similar to CREB-BINDING PROTEIN.
AK304771 - Homo sapiens cDNA FLJ57039 partial cds, highly similar to CREB-binding protein (EC 2.3.1.48).
AJ251845 - Homo sapiens partial mRNA for CBP/MOZ chimeric transcript.
JD488562 - Sequence 469586 from Patent EP1572962.
JD408431 - Sequence 389455 from Patent EP1572962.
JD140499 - Sequence 121523 from Patent EP1572962.
JD164327 - Sequence 145351 from Patent EP1572962.
MK172839 - Homo sapiens CREBBP/SRGAP2B fusion, partial sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04110 - Cell cycle
hsa04310 - Wnt signaling pathway
hsa04330 - Notch signaling pathway
hsa04350 - TGF-beta signaling pathway
hsa04520 - Adherens junction
hsa04630 - Jak-STAT signaling pathway
hsa04720 - Long-term potentiation
hsa04916 - Melanogenesis
hsa05016 - Huntington's disease
hsa05200 - Pathways in cancer
hsa05211 - Renal cell carcinoma
hsa05215 - Prostate cancer

BioCarta from NCI Cancer Genome Anatomy Project
h_pelp1Pathway - Pelp1 Modulation of Estrogen Receptor Activity
h_pitx2Pathway - Multi-step Regulation of Transcription by Pitx2
h_wntPathway - WNT Signaling Pathway
h_tgfbPathway - TGF beta signaling pathway
h_pcafpathway - The information-processing pathway at the IFN-beta enhancer
h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)
h_il7Pathway - IL-7 Signal Transduction
h_HuntingtonPathway - Inhibition of Huntington's disease neurodegeneration by histone deacetylase inhibitors
h_pmlPathway - Regulation of transcriptional activity by PML
h_RELAPathway - Acetylation and Deacetylation of RelA in The Nucleus
h_nthiPathway - NFkB activation by Nontypeable Hemophilus influenzae
h_ppargPathway - Role of PPAR-gamma Coactivators in Obesity and Thermogenesis
h_CSKPathway - Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor
h_carm-erPathway - CARM1 and Regulation of the Estrogen Receptor
h_carm1Pathway - Transcription Regulation by Methyltransferase of CARM1
h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart)
h_setPathway - Granzyme A mediated Apoptosis Pathway
h_vdrPathway - Control of Gene Expression by Vitamin D Receptor

Reactome (by CSHL, EBI, and GO)

Protein Q92793 (Reactome details) participates in the following event(s):

R-HSA-212356 Formation of CSL-NICD coactivator complex
R-HSA-381309 PPARG:RXRA heterodimer binds to fatty acid-like ligands
R-HSA-1912394 NICD1 in complex with RBPJ (CSL) recruits MAML
R-HSA-2220964 NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML
R-HSA-6797993 TP53 and CREBBP bind BNIP3L gene
R-HSA-8864307 TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP
R-HSA-8938231 RUNX1:CBFB binds CREBBP
R-HSA-9038052 GREB1 binds ESR1:ESTG and co-activators
R-HSA-1912391 NICD1 is phosphorylated by CDK8
R-HSA-2220971 CDK8 phosphorylates NICD1 PEST domain mutants
R-HSA-1912393 MAML in complex with NICD1 recruits CDK8
R-HSA-4396347 NOTCH1 Coactivator Complex binds HES1 promoter
R-HSA-4396371 NOTCH1 Coactivator Complex binds MYC promoter
R-HSA-4396379 NOTCH1 Coactivator Complex binds HES5 promoter
R-HSA-4396382 NOTCH1 Coactivator Complex binds promoters of HEY genes
R-HSA-8878220 RUNX3 binds the NOTCH1 coactivator complex
R-HSA-9017835 NOTCH1 coactivator complex binds NOTCH3 gene
R-HSA-2220957 NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC
R-HSA-4396392 NOTCH1 PEST domain mutants bind HES1 promoter
R-HSA-4396393 NOTCH1 PEST domain mutants bind MYC promoter
R-HSA-4396401 NOTCH1 PEST domain mutants bind HES5 promoter
R-HSA-4396402 NOTCH1 PEST domain mutants bind promoters of HEY genes
R-HSA-4395227 CCND1:CREBBP binds NOTCH1 promoter
R-HSA-8938228 RUNX1:CBFB:CREBBP binds the CSF2 (GM-CSF) gene promoter
R-HSA-400143 Fatty acid ligands activate PPARA
R-HSA-933536 p-IRF7 dimer interacts with coactivator CBP/p300
R-HSA-1028817 CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3
R-HSA-1028820 Formation of VAF (virus-activated factor) complex
R-HSA-3134883 Beta-catenin enhances association of IRF3 with CBP/p300
R-HSA-3322427 Beta-catenin recruits CBP/p300
R-HSA-5660666 CBP and p300 binds NF-kB complex
R-HSA-3697008 CREBBP acetylates histone H2B, H3, H4
R-HSA-8878237 RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter
R-HSA-9021451 NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter
R-HSA-1028815 p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta
R-HSA-5660660 p300 acetylates RELA subunit
R-HSA-3371554 HSF1 acetylation at Lys80
R-HSA-1028819 VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes
R-HSA-157052 NICD traffics to nucleus
R-HSA-350054 Notch-HLH transcription pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors
R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-8941856 RUNX3 regulates NOTCH signaling
R-HSA-1912408 Pre-NOTCH Transcription and Translation
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-918233 TRAF3-dependent IRF activation pathway
R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-5621575 CD209 (DC-SIGN) signaling
R-HSA-212436 Generic Transcription Pathway
R-HSA-1266738 Developmental Biology
R-HSA-1234174 Regulation of Hypoxia-inducible Factor (HIF) by oxygen
R-HSA-1980143 Signaling by NOTCH1
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-5619507 Activation of HOX genes during differentiation
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-8939211 ESR-mediated signaling
R-HSA-3214847 HATs acetylate histones
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription
R-HSA-8878159 Transcriptional regulation by RUNX3
R-HSA-1912422 Pre-NOTCH Expression and Processing
R-HSA-556833 Metabolism of lipids
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-3371568 Attenuation phase
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-2262749 Cellular response to hypoxia
R-HSA-157118 Signaling by NOTCH
R-HSA-2644603 Signaling by NOTCH1 in Cancer
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-9012852 Signaling by NOTCH3
R-HSA-1430728 Metabolism
R-HSA-168249 Innate Immune System
R-HSA-195721 Signaling by WNT
R-HSA-3371571 HSF1-dependent transactivation
R-HSA-74160 Gene expression (Transcription)
R-HSA-2262752 Cellular responses to stress
R-HSA-162582 Signal Transduction
R-HSA-5663202 Diseases of signal transduction
R-HSA-4839726 Chromatin organization
R-HSA-168256 Immune System
R-HSA-3371556 Cellular response to heat stress
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: CBP, CBP_HUMAN, D3DUC9, ENST00000262367.1, ENST00000262367.2, ENST00000262367.3, ENST00000262367.4, ENST00000262367.5, ENST00000262367.6, ENST00000262367.7, ENST00000262367.8, ENST00000262367.9, NM_004380, O00147, Q16376, Q92793, uc002cvv.1, uc002cvv.2, uc002cvv.3, uc002cvv.4, uc002cvv.5
UCSC ID: ENST00000262367.10
RefSeq Accession: NM_004380
Protein: Q92793 (aka CBP_HUMAN)
CCDS: CCDS10509.1, CCDS45399.1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene CREBBP:
rsts (Rubinstein-Taybi Syndrome)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.