Human Gene GNAO1 (ENST00000262494.13) from GENCODE V44
Description: Homo sapiens G protein subunit alpha o1 (GNAO1), transcript variant 2, mRNA. (from RefSeq NM_138736) RefSeq Summary (NM_138736): The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]. Gencode Transcript: ENST00000262494.13 Gencode Gene: ENSG00000087258.16 Transcript (Including UTRs) Position: hg38 chr16:56,191,489-56,348,199 Size: 156,711 Total Exon Count: 8 Strand: + Coding Region Position: hg38 chr16:56,192,236-56,343,950 Size: 151,715 Coding Exon Count: 8
ID:GNAO_HUMAN DESCRIPTION: RecName: Full=Guanine nucleotide-binding protein G(o) subunit alpha; FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. SUBUNIT: Interacts with RGS14 (By similarity). G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. SIMILARITY: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P09471
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.