Human Gene FHOD1 (ENST00000258201.9) from GENCODE V44
Description: Homo sapiens formin homology 2 domain containing 1 (FHOD1), transcript variant 2, mRNA. (from RefSeq NM_013241) RefSeq Summary (NM_013241): This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]. Gencode Transcript: ENST00000258201.9 Gencode Gene: ENSG00000135723.14 Transcript (Including UTRs) Position: hg38 chr16:67,229,389-67,247,481 Size: 18,093 Total Exon Count: 22 Strand: - Coding Region Position: hg38 chr16:67,229,636-67,247,410 Size: 17,775 Coding Exon Count: 22
ID:FHOD1_HUMAN DESCRIPTION: RecName: Full=FH1/FH2 domain-containing protein 1; AltName: Full=Formin homolog overexpressed in spleen 1; Short=FHOS; AltName: Full=Formin homology 2 domain-containing protein 1; FUNCTION: Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. SUBUNIT: Self-associates via the FH2 domain. Binds to F-actin via its N-terminus. Binds to the cytoplasmic domain of CD21 via its C- terminus. Interacts with ROCK1 in a Src-dependent manner. SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, bleb. Note=Predominantly cytoplasmic. TISSUE SPECIFICITY: Ubiquitous. Highly expressed in spleen. DOMAIN: The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments. PTM: Phosphorylated by ROCK1. SIMILARITY: Belongs to the formin homology family. SIMILARITY: Contains 1 DAD (diaphanous autoregulatory) domain. SIMILARITY: Contains 1 FH1 (formin homology 1) domain. SIMILARITY: Contains 1 FH2 (formin homology 2) domain. SIMILARITY: Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y613
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
