Human Gene CALB2 (ENST00000302628.9) from GENCODE V44
Description: Homo sapiens calbindin 2 (CALB2), transcript variant CALB2b, non-coding RNA. (from RefSeq NR_027910) RefSeq Summary (NM_001740): This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]. Gencode Transcript: ENST00000302628.9 Gencode Gene: ENSG00000172137.19 Transcript (Including UTRs) Position: hg38 chr16:71,358,723-71,390,433 Size: 31,711 Total Exon Count: 11 Strand: + Coding Region Position: hg38 chr16:71,358,793-71,389,865 Size: 31,073 Coding Exon Count: 11
ID:CALB2_HUMAN DESCRIPTION: RecName: Full=Calretinin; Short=CR; AltName: Full=29 kDa calbindin; FUNCTION: Calretinin is a calcium-binding protein which is abundant in auditory neurons. TISSUE SPECIFICITY: Brain. SIMILARITY: Belongs to the calbindin family. SIMILARITY: Contains 6 EF-hand domains. WEB RESOURCE: Name=Wikipedia; Note=Calbindin entry; URL="http://en.wikipedia.org/wiki/Calbindin";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P22676
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
