Human Gene IST1 (ENST00000378799.11) from GENCODE V44
Description: Homo sapiens IST1 factor associated with ESCRT-III (IST1), transcript variant 1, mRNA. (from RefSeq NM_001270975) RefSeq Summary (NM_001270975): This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]. Gencode Transcript: ENST00000378799.11 Gencode Gene: ENSG00000182149.21 Transcript (Including UTRs) Position: hg38 chr16:71,895,531-71,931,199 Size: 35,669 Total Exon Count: 10 Strand: + Coding Region Position: hg38 chr16:71,915,641-71,927,813 Size: 12,173 Coding Exon Count: 9
ID:IST1_HUMAN DESCRIPTION: RecName: Full=IST1 homolog; Short=hIST1; AltName: Full=Putative MAPK-activating protein PM28; FUNCTION: Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. SUBUNIT: Interacts with CHMP1A, CHMP1B, VPS4A and VTA1. Interacts with SPAST, STAMBP, USP8 and MITD1. May interact with VPS37B. May associate with the ESCRT-I complex. INTERACTION: P54253:ATXN1; NbExp=2; IntAct=EBI-945994, EBI-930964; SUBCELLULAR LOCATION: Cytoplasmic vesicle. Note=Localizes to the midbody of dividing cells. SIMILARITY: Belongs to the IST1 family. SEQUENCE CAUTION: Sequence=BAA11491.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P53990
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.