Human Gene HPR (ENST00000540303.7) from GENCODE V44
Description: Homo sapiens haptoglobin-related protein (HPR), transcript variant 1, mRNA. (from RefSeq NM_020995) RefSeq Summary (NM_020995): This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]. Gencode Transcript: ENST00000540303.7 Gencode Gene: ENSG00000261701.9 Transcript (Including UTRs) Position: hg38 chr16:72,063,226-72,077,246 Size: 14,021 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr16:72,063,256-72,077,081 Size: 13,826 Coding Exon Count: 5
ID:HPTR_HUMAN DESCRIPTION: RecName: Full=Haptoglobin-related protein; Flags: Precursor; SUBCELLULAR LOCATION: Secreted (Potential). TISSUE SPECIFICITY: In adult liver the amount of HPR mRNA is at the lower limit of detection, therefore the extent of its expression is at most less than 1000-fold that of the HP1F gene. No HPR mRNA can be detected in fetal liver. Expressed in Hep-G2 and leukemia MOLT-4 cell lines. SIMILARITY: Belongs to the peptidase S1 family. SIMILARITY: Contains 1 peptidase S1 domain. SIMILARITY: Contains 1 Sushi (CCP/SCR) domain. CAUTION: Although homologous to serine proteases, it has lost all essential catalytic residues and has no enzymatic activity.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P00739
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
X89214 - H.sapiens mRNA for haptoglobin related protein. BC160066 - Synthetic construct Homo sapiens clone IMAGE:100064002, MGC:193181 haptoglobin-related protein (HPR) mRNA, encodes complete protein. JD199811 - Sequence 180835 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P00739 (Reactome details) participates in the following event(s):
R-HSA-2168889 Haptoglobin-related Protein binds Hemoglobin R-HSA-2168880 Scavenging of heme from plasma R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors R-HSA-5653656 Vesicle-mediated transport
US Server
