Human Gene SLC43A2 (ENST00000301335.10) from GENCODE V44
Description: Homo sapiens solute carrier family 43 member 2 (SLC43A2), transcript variant 2, mRNA. (from RefSeq NM_152346) RefSeq Summary (NM_152346): This gene encodes a member of the L-amino acid transporter-3 or SLC43 family of transporters. The encoded protein mediates sodium-, chloride-, and pH-independent transport of L-isomers of neutral amino acids, including leucine, phenylalanine, valine and methionine. This protein may contribute to the transfer of amino acids across the placental membrane to the fetus. [provided by RefSeq, Mar 2016]. Gencode Transcript: ENST00000301335.10 Gencode Gene: ENSG00000167703.15 Transcript (Including UTRs) Position: hg38 chr17:1,569,268-1,628,834 Size: 59,567 Total Exon Count: 14 Strand: - Coding Region Position: hg38 chr17:1,575,604-1,627,874 Size: 52,271 Coding Exon Count: 13
ID:LAT4_HUMAN DESCRIPTION: RecName: Full=Large neutral amino acids transporter small subunit 4; AltName: Full=L-type amino acid transporter 4; AltName: Full=Solute carrier family 43 member 2; FUNCTION: Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (By similarity). TISSUE SPECIFICITY: Detected in several tissues with higher expression in placenta, kidney and peripheral blood leukocytes. In the kidney, is detected in epithelial cells of the distal tubule and collecting duct. In the intestine, is expressed mainly in crypt cells of the intestinal microvilli and epithelial cells in the base of the villus. PTM: Glycosylated (By similarity). SIMILARITY: Belongs to the SLC43A transporter (TC 2.A.1.44) family. SEQUENCE CAUTION: Sequence=BAC11383.1; Type=Erroneous initiation; Sequence=BAC11450.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF07690 - Major Facilitator Superfamily
ModBase Predicted Comparative 3D Structure on Q8N370
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0003333 amino acid transmembrane transport GO:0006865 amino acid transport GO:0015804 neutral amino acid transport GO:0015807 L-amino acid transport GO:0055085 transmembrane transport GO:1902475 L-alpha-amino acid transmembrane transport
AK056769 - Homo sapiens cDNA FLJ32207 fis, clone PLACE6003204. JD112507 - Sequence 93531 from Patent EP1572962. JD144747 - Sequence 125771 from Patent EP1572962. JD411900 - Sequence 392924 from Patent EP1572962. JD438876 - Sequence 419900 from Patent EP1572962. JD112139 - Sequence 93163 from Patent EP1572962. JD420192 - Sequence 401216 from Patent EP1572962. JD291787 - Sequence 272811 from Patent EP1572962. JD291788 - Sequence 272812 from Patent EP1572962. JD446463 - Sequence 427487 from Patent EP1572962. JD484963 - Sequence 465987 from Patent EP1572962. JD519902 - Sequence 500926 from Patent EP1572962. JD249137 - Sequence 230161 from Patent EP1572962. JD148086 - Sequence 129110 from Patent EP1572962. JD148324 - Sequence 129348 from Patent EP1572962. JD463684 - Sequence 444708 from Patent EP1572962. JD478450 - Sequence 459474 from Patent EP1572962. JD543115 - Sequence 524139 from Patent EP1572962. JD543275 - Sequence 524299 from Patent EP1572962. JD139146 - Sequence 120170 from Patent EP1572962. JD142565 - Sequence 123589 from Patent EP1572962. JD222910 - Sequence 203934 from Patent EP1572962. JD202974 - Sequence 183998 from Patent EP1572962. JD214269 - Sequence 195293 from Patent EP1572962. JD515878 - Sequence 496902 from Patent EP1572962. JD297169 - Sequence 278193 from Patent EP1572962. JD138239 - Sequence 119263 from Patent EP1572962. JD066629 - Sequence 47653 from Patent EP1572962. JD073064 - Sequence 54088 from Patent EP1572962. JD444797 - Sequence 425821 from Patent EP1572962. JD211796 - Sequence 192820 from Patent EP1572962. JD511618 - Sequence 492642 from Patent EP1572962. JD216090 - Sequence 197114 from Patent EP1572962. JD455931 - Sequence 436955 from Patent EP1572962. JD530044 - Sequence 511068 from Patent EP1572962. JD061122 - Sequence 42146 from Patent EP1572962. JD439895 - Sequence 420919 from Patent EP1572962. JD137746 - Sequence 118770 from Patent EP1572962. JD455549 - Sequence 436573 from Patent EP1572962. JD555767 - Sequence 536791 from Patent EP1572962. JD513803 - Sequence 494827 from Patent EP1572962. JD187535 - Sequence 168559 from Patent EP1572962. JD446647 - Sequence 427671 from Patent EP1572962. JD155033 - Sequence 136057 from Patent EP1572962. JD444258 - Sequence 425282 from Patent EP1572962. JD544628 - Sequence 525652 from Patent EP1572962. JD135231 - Sequence 116255 from Patent EP1572962. JD470726 - Sequence 451750 from Patent EP1572962. JD339851 - Sequence 320875 from Patent EP1572962. JD458168 - Sequence 439192 from Patent EP1572962. JD047182 - Sequence 28206 from Patent EP1572962. JD062094 - Sequence 43118 from Patent EP1572962. JD393558 - Sequence 374582 from Patent EP1572962. JD424010 - Sequence 405034 from Patent EP1572962. JD153412 - Sequence 134436 from Patent EP1572962. JD133309 - Sequence 114333 from Patent EP1572962. JD289960 - Sequence 270984 from Patent EP1572962. JD494139 - Sequence 475163 from Patent EP1572962. JD068557 - Sequence 49581 from Patent EP1572962. JD131988 - Sequence 113012 from Patent EP1572962. JD507382 - Sequence 488406 from Patent EP1572962. JD256961 - Sequence 237985 from Patent EP1572962. JD152422 - Sequence 133446 from Patent EP1572962. JD119101 - Sequence 100125 from Patent EP1572962. JD220792 - Sequence 201816 from Patent EP1572962. JD278352 - Sequence 259376 from Patent EP1572962. JD545188 - Sequence 526212 from Patent EP1572962. AB120364 - Homo sapiens SLC43A2 mRNA for L-type amino acid transporter 4, complete cds. AK075196 - Homo sapiens cDNA FLJ90715 fis, clone PLACE1008469. AK074428 - Homo sapiens cDNA FLJ23848 fis, clone KAT10935. BC019562 - Homo sapiens solute carrier family 43, member 2, mRNA (cDNA clone IMAGE:3451144), partial cds. BC027923 - Homo sapiens solute carrier family 43, member 2, mRNA (cDNA clone MGC:34680 IMAGE:5309751), complete cds. AK075068 - Homo sapiens cDNA FLJ90587 fis, clone PLACE1000914, weakly similar to Homo sapiens PB39 mRNA. AK075173 - Homo sapiens cDNA FLJ90692 fis, clone PLACE1006443, weakly similar to Homo sapiens PB39 mRNA. JD118974 - Sequence 99998 from Patent EP1572962. JD492132 - Sequence 473156 from Patent EP1572962. JD456642 - Sequence 437666 from Patent EP1572962. DQ592377 - Homo sapiens piRNA piR-59489, complete sequence. JD142177 - Sequence 123201 from Patent EP1572962. JD322601 - Sequence 303625 from Patent EP1572962. JD111529 - Sequence 92553 from Patent EP1572962. JD455963 - Sequence 436987 from Patent EP1572962. JD077547 - Sequence 58571 from Patent EP1572962. JD526686 - Sequence 507710 from Patent EP1572962. JD548379 - Sequence 529403 from Patent EP1572962. JD222125 - Sequence 203149 from Patent EP1572962. JD396625 - Sequence 377649 from Patent EP1572962. AK301127 - Homo sapiens cDNA FLJ55865 complete cds, highly similar to Homo sapiens solute carrier family 43, member 2 (SLC43A2), mRNA. JD227194 - Sequence 208218 from Patent EP1572962. JD060161 - Sequence 41185 from Patent EP1572962. JD399292 - Sequence 380316 from Patent EP1572962. KJ895398 - Synthetic construct Homo sapiens clone ccsbBroadEn_04792 SLC43A2 gene, encodes complete protein. AF289592 - Homo sapiens clone pp7664 unknown mRNA. BC071859 - Homo sapiens solute carrier family 43, member 2, mRNA (cDNA clone MGC:88527 IMAGE:6572285), complete cds. CU687184 - Synthetic construct Homo sapiens gateway clone IMAGE:100023168 5' read SLC43A2 mRNA. CU693318 - Synthetic construct Homo sapiens gateway clone IMAGE:100017411 5' read SLC43A2 mRNA.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8N370 (Reactome details) participates in the following event(s):
R-HSA-352107 Metabolism of nitrogenous molecules R-HSA-352230 Amino acid transport across the plasma membrane R-HSA-425374 Amino acid and oligopeptide SLC transporters R-HSA-425393 Metabolism of nitrogenous molecules R-HSA-425407 SLC-mediated transmembrane transport R-HSA-382551 Transport of small molecules