Human Gene CXCL16 (ENST00000293778.12) from GENCODE V44
Description: Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. (from UniProt Q9H2A7) Gencode Transcript: ENST00000293778.12 Gencode Gene: ENSG00000161921.17 Transcript (Including UTRs) Position: hg38 chr17:4,733,533-4,739,928 Size: 6,396 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr17:4,734,606-4,739,339 Size: 4,734 Coding Exon Count: 5
ID:CXL16_HUMAN DESCRIPTION: RecName: Full=C-X-C motif chemokine 16; AltName: Full=Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein; Short=SR-PSOX; AltName: Full=Small-inducible cytokine B16; AltName: Full=Transmembrane chemokine CXCL16; Flags: Precursor; FUNCTION: Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (Potential). Secreted. Note=Also exists as a soluble form. TISSUE SPECIFICITY: Expressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow. PTM: Glycosylated. SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family. SEQUENCE CAUTION: Sequence=AAG34365.1; Type=Erroneous initiation; Sequence=AAH17588.1; Type=Erroneous initiation; Sequence=AAH44930.1; Type=Erroneous initiation; Sequence=ABK41925.1; Type=Erroneous initiation; Sequence=BAB55078.1; Type=Erroneous initiation; Sequence=BAF84803.1; Type=Erroneous initiation; Sequence=BAG37507.1; Type=Erroneous initiation; WEB RESOURCE: Name=Wikipedia; Note=CXCL16 entry; URL="http://en.wikipedia.org/wiki/CXCL16";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H2A7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
