ID:RFFL_HUMAN DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase rififylin; EC=6.3.2.-; AltName: Full=Caspase regulator CARP2; AltName: Full=Caspases-8 and -10-associated RING finger protein 2; Short=CARP-2; AltName: Full=FYVE-RING finger protein Sakura; Short=Fring; AltName: Full=RING finger and FYVE-like domain-containing protein 1; AltName: Full=RING finger protein 189; AltName: Full=RING finger protein 34-like; FUNCTION: Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Binds CASP8 and CASP10. SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. TISSUE SPECIFICITY: Ubiquitous. Detected in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. PTM: Rapidly degraded after stimulation with TNFSF10, probably by caspases. PTM: Auto-ubiquitinated (in vitro) (By similarity). PTM: Palmitoylated (By similarity). SIMILARITY: Contains 1 FYVE-type zinc finger. SIMILARITY: Contains 1 RING-type zinc finger. SIMILARITY: Contains 2 SAP domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8WZ73
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006511 ubiquitin-dependent protein catabolic process GO:0006915 apoptotic process GO:0010762 regulation of fibroblast migration GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway GO:0016567 protein ubiquitination GO:0032006 regulation of TOR signaling GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0070936 protein K48-linked ubiquitination GO:1901797 negative regulation of signal transduction by p53 class mediator GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis