Human Gene KRT33A (ENST00000007735.4) from GENCODE V44
Description: Homo sapiens keratin 33A (KRT33A), mRNA. (from RefSeq NM_004138) RefSeq Summary (NM_004138): This gene encodes a member of the keratin gene family. This gene is one of multiple type I hair keratin genes that are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. As a type I hair keratin, the encoded protein is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, keratin 33A and keratin 33B. [provided by RefSeq, May 2012]. Gencode Transcript: ENST00000007735.4 Gencode Gene: ENSG00000006059.4 Transcript (Including UTRs) Position: hg38 chr17:41,346,092-41,350,828 Size: 4,737 Total Exon Count: 7 Strand: - Coding Region Position: hg38 chr17:41,346,119-41,350,767 Size: 4,649 Coding Exon Count: 7
ID:KT33A_HUMAN DESCRIPTION: RecName: Full=Keratin, type I cuticular Ha3-I; AltName: Full=Hair keratin, type I Ha3-I; AltName: Full=Keratin-33A; Short=K33A; TISSUE SPECIFICITY: Expressed in the hair follicles. MISCELLANEOUS: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic). SIMILARITY: Belongs to the intermediate filament family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00038 - Intermediate filament protein
ModBase Predicted Comparative 3D Structure on O76009
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.