Human Gene RNF43 (ENST00000407977.7) from GENCODE V44
Description: Homo sapiens ring finger protein 43 (RNF43), transcript variant 1, mRNA. (from RefSeq NM_017763) RefSeq Summary (NM_017763): The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]. Gencode Transcript: ENST00000407977.7 Gencode Gene: ENSG00000108375.13 Transcript (Including UTRs) Position: hg38 chr17:58,353,676-58,417,534 Size: 63,859 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr17:58,354,943-58,415,577 Size: 60,635 Coding Exon Count: 9
ID:RNF43_HUMAN DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase RNF43; EC=6.3.2.-; AltName: Full=RING finger protein 43; Flags: Precursor; FUNCTION: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with AKAP8L, NONO and SFPQ. Interacts with FZD5. INTERACTION: Q9ULX6:AKAP8L; NbExp=2; IntAct=EBI-1647060, EBI-357530; P0CG47:UBB; NbExp=2; IntAct=EBI-1647060, EBI-413034; P62837:UBE2D2; NbExp=2; IntAct=EBI-1647060, EBI-347677; P61077:UBE2D3; NbExp=2; IntAct=EBI-1647060, EBI-348268; SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope. Note=According to a report, may be secreted (PubMed:15492824). TISSUE SPECIFICITY: Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines. PTM: Autoubiquitinated. MISCELLANEOUS: Acts as a cytotoxic T-lymphocyte tumor antigen, suggesting that it may be used as a target for cancer immunotherapy (PubMed:15623641). SIMILARITY: Belongs to the ZNRF3 family. SIMILARITY: Contains 1 RING-type zinc finger. SEQUENCE CAUTION: Sequence=BAH12871.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q68DV7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
