Human Gene PSMD12 (ENST00000356126.8) from GENCODE V44
Description: Homo sapiens proteasome 26S subunit, non-ATPase 12 (PSMD12), transcript variant 1, mRNA. (from RefSeq NM_002816) RefSeq Summary (NM_002816): The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]. Gencode Transcript: ENST00000356126.8 Gencode Gene: ENSG00000197170.10 Transcript (Including UTRs) Position: hg38 chr17:67,337,916-67,366,577 Size: 28,662 Total Exon Count: 11 Strand: - Coding Region Position: hg38 chr17:67,340,843-67,366,519 Size: 25,677 Coding Exon Count: 11
ID:PSD12_HUMAN DESCRIPTION: RecName: Full=26S proteasome non-ATPase regulatory subunit 12; AltName: Full=26S proteasome regulatory subunit RPN5; AltName: Full=26S proteasome regulatory subunit p55; FUNCTION: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. SUBUNIT: Component of the PA700 complex. SIMILARITY: Belongs to the proteasome subunit p55 family. SIMILARITY: Contains 1 PCI domain. SEQUENCE CAUTION: Sequence=AAH65826.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O00232
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0016579 protein deubiquitination GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043312 neutrophil degranulation GO:0043687 post-translational protein modification