Human Gene LLGL2 (ENST00000392550.8) from GENCODE V44
Description: Homo sapiens LLGL scribble cell polarity complex component 2 (LLGL2), transcript variant 3, mRNA. (from RefSeq NM_001031803) RefSeq Summary (NM_001031803): The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000392550.8 Gencode Gene: ENSG00000073350.14 Transcript (Including UTRs) Position: hg38 chr17:75,525,697-75,575,209 Size: 49,513 Total Exon Count: 26 Strand: + Coding Region Position: hg38 chr17:75,543,427-75,574,878 Size: 31,452 Coding Exon Count: 25
ID:L2GL2_HUMAN DESCRIPTION: RecName: Full=Lethal(2) giant larvae protein homolog 2; AltName: Full=HGL; FUNCTION: Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. SUBUNIT: Interacts with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6. The complex is enhanced during mitosis. SUBCELLULAR LOCATION: Cytoplasm. Note=Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells. PTM: Phosphorylated at Ser-653 by PRKCI. Phosphorylation is enhanced during cell polarization induced by calcium. Phosphorylation may occur during the cell-cell contact-induced cell polarization and may contribute to the segregation of LLGL2 from the PRKCI/aPKC and PARD6B/Par-6 complex. MISCELLANEOUS: Overexpression of LLGL2 inhibits the tight junction formation. SIMILARITY: Belongs to the WD repeat L(2)GL family. SIMILARITY: Contains 14 WD repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6P1M3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006887 exocytosis GO:0007049 cell cycle GO:0017157 regulation of exocytosis GO:0032878 regulation of establishment or maintenance of cell polarity GO:0043547 positive regulation of GTPase activity GO:0050708 regulation of protein secretion GO:0051301 cell division
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