Human Gene ZACN (ENST00000334586.10) from GENCODE V44
Description: Homo sapiens zinc activated ion channel (ZACN), mRNA. (from RefSeq NM_180990) RefSeq Summary (NM_180990): LGICZ1 is a zinc-activated ligand-gated ion channel that defines a new subgroup of the cysteine-loop superfamily of ligand-gated ion channels (Davies et al., 2003 [PubMed 12381728]).[supplied by OMIM, Mar 2008]. Gencode Transcript: ENST00000334586.10 Gencode Gene: ENSG00000186919.13 Transcript (Including UTRs) Position: hg38 chr17:76,079,182-76,082,806 Size: 3,625 Total Exon Count: 9 Strand: + Coding Region Position: hg38 chr17:76,079,265-76,082,653 Size: 3,389 Coding Exon Count: 9
ID:ZACN_HUMAN DESCRIPTION: RecName: Full=Zinc-activated ligand-gated ion channel; AltName: Full=Ligand-gated ion channel zinc-activated 1; AltName: Full=Ligand-gated ion-channel receptor L2; Flags: Precursor; FUNCTION: Zinc-activated ligand-gated ion channel. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Detected in pancreas, brain, liver, placenta, trachea, kidney, spinal cord, stomach and fetal brain. In the adult brain region expression is detected in the hippocampus, striatum, amygdala and thalamus. PTM: Glycosylated. MISCELLANEOUS: The mouse and rat orthologous proteins do not exist. SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family. CAUTION: It is uncertain whether Met-1 or Met-2 is the initiator. SEQUENCE CAUTION: Sequence=AAI10598.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAO20969.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAW89365.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q401N2
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004888 transmembrane signaling receptor activity GO:0005216 ion channel activity GO:0005230 extracellular ligand-gated ion channel activity GO:0008270 zinc ion binding GO:0015276 ligand-gated ion channel activity GO:0022850 serotonin-gated cation channel activity