Human Gene CYGB (ENST00000293230.10) from GENCODE V44
Description: Homo sapiens cytoglobin (CYGB), mRNA. (from RefSeq NM_134268) RefSeq Summary (NM_134268): This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation. [provided by RefSeq, Jan 2012]. Gencode Transcript: ENST00000293230.10 Gencode Gene: ENSG00000161544.10 Transcript (Including UTRs) Position: hg38 chr17:76,527,356-76,537,709 Size: 10,354 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr17:76,528,578-76,537,542 Size: 8,965 Coding Exon Count: 4
ID:CYGB_HUMAN DESCRIPTION: RecName: Full=Cytoglobin; AltName: Full=Histoglobin; Short=HGb; AltName: Full=Stellate cell activation-associated protein; FUNCTION: May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer. SUBUNIT: Homodimer; disulfide-linked. SUBCELLULAR LOCATION: Cytoplasm (By similarity). TISSUE SPECIFICITY: Ubiquitously expressed. Highest expression in heart, stomach, bladder and small intestine. SIMILARITY: Belongs to the globin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8WWM9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.