Human Gene LGALS3BP (ENST00000262776.8) from GENCODE V44
  Description: Homo sapiens galectin 3 binding protein (LGALS3BP), mRNA. (from RefSeq NM_005567)
RefSeq Summary (NM_005567): The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000262776.8
Gencode Gene: ENSG00000108679.13
Transcript (Including UTRs)
   Position: hg38 chr17:78,971,255-78,979,923 Size: 8,669 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg38 chr17:78,971,576-78,977,191 Size: 5,616 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:78,971,255-78,979,923)mRNA (may differ from genome)Protein (585 aa)
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HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: LG3BP_HUMAN
DESCRIPTION: RecName: Full=Galectin-3-binding protein; AltName: Full=Basement membrane autoantigen p105; AltName: Full=Lectin galactoside-binding soluble 3-binding protein; AltName: Full=Mac-2-binding protein; Short=MAC2BP; Short=Mac-2 BP; AltName: Full=Tumor-associated antigen 90K; Flags: Precursor;
FUNCTION: Promotes intergrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
SUBUNIT: Homodimers and homomultimers. The multimers form ring- like structures with a diameter of 30-40 nm. Binds LGALS1 and LGALS3. Binds ITGB1, COL4A1, COL5A1, COL6A1, FN1 and NID.
SUBCELLULAR LOCATION: Secreted. Secreted, extracellular space, extracellular matrix.
TISSUE SPECIFICITY: Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts.
SIMILARITY: Contains 1 BACK (BTB/Kelch associated) domain.
SIMILARITY: Contains 1 BTB (POZ) domain.
SIMILARITY: Contains 1 SRCR domain.

-  Primer design for this transcript
 

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-  MalaCards Disease Associations
  MalaCards Gene Search: LGALS3BP
Diseases sorted by gene-association score: ostertagiasis (3), trichostrongyloidiasis (2), colorectal cancer (2), epithelioid cell melanoma (2), ovarian cancer, somatic (2), dyskinetic cerebral palsy (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 190.56 RPKM in Adrenal Gland
Total median expression: 3432.77 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -43.30123-0.352 Picture PostScript Text
3' UTR -94.50321-0.294 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011705 - BACK
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR001190 - Srcr_rcpt
IPR017448 - Srcr_rcpt-rel

Pfam Domains:
PF07707 - BTB And C-terminal Kelch
PF00530 - Scavenger receptor cysteine-rich domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1BY2 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q08380
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005044 scavenger receptor activity
GO:0005515 protein binding

Biological Process:
GO:0002576 platelet degranulation
GO:0006898 receptor-mediated endocytosis
GO:0006968 cellular defense response
GO:0007155 cell adhesion
GO:0007165 signal transduction

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0016020 membrane
GO:0031012 extracellular matrix
GO:0031089 platelet dense granule lumen
GO:0070062 extracellular exosome
GO:0072562 blood microparticle


-  Descriptions from all associated GenBank mRNAs
  LF209435 - JP 2014500723-A/16938: Polycomb-Associated Non-Coding RNAs.
MA445012 - JP 2018138019-A/16938: Polycomb-Associated Non-Coding RNAs.
BC015761 - Homo sapiens lectin, galactoside-binding, soluble, 3 binding protein, mRNA (cDNA clone MGC:23157 IMAGE:4858122), complete cds.
AK055977 - Homo sapiens cDNA FLJ31415 fis, clone NT2NE2000284, highly similar to Galectin-3-binding protein precursor.
BC002403 - Homo sapiens lectin, galactoside-binding, soluble, 3 binding protein, mRNA (cDNA clone MGC:8513 IMAGE:2822371), complete cds.
BC002998 - Homo sapiens lectin, galactoside-binding, soluble, 3 binding protein, mRNA (cDNA clone MGC:3900 IMAGE:2822371), complete cds.
X79089 - H.sapiens mRNA for 90K product.
AK307665 - Homo sapiens cDNA, FLJ97613.
AK301444 - Homo sapiens cDNA FLJ53427 complete cds, highly similar to Galectin-3-binding protein precursor.
AK057776 - Homo sapiens cDNA FLJ25047 fis, clone CBL03638, highly similar to Human Mac-2 binding protein mRNA.
AK293183 - Homo sapiens cDNA FLJ54583 complete cds, highly similar to Galectin-3-binding protein precursor.
L13210 - Human Mac-2 binding protein mRNA, complete cds.
LF328513 - JP 2014500723-A/136016: Polycomb-Associated Non-Coding RNAs.
MA564090 - JP 2018138019-A/136016: Polycomb-Associated Non-Coding RNAs.
JD375415 - Sequence 356439 from Patent EP1572962.
JD098282 - Sequence 79306 from Patent EP1572962.
JD364851 - Sequence 345875 from Patent EP1572962.
JD309506 - Sequence 290530 from Patent EP1572962.
AK301040 - Homo sapiens cDNA FLJ53478 complete cds, highly similar to Galectin-3-binding protein precursor.
JD181422 - Sequence 162446 from Patent EP1572962.
AK295442 - Homo sapiens cDNA FLJ53509 complete cds, highly similar to Galectin-3-binding protein precursor.
JD319090 - Sequence 300114 from Patent EP1572962.
JD107783 - Sequence 88807 from Patent EP1572962.
JD156368 - Sequence 137392 from Patent EP1572962.
LF328514 - JP 2014500723-A/136017: Polycomb-Associated Non-Coding RNAs.
MA564091 - JP 2018138019-A/136017: Polycomb-Associated Non-Coding RNAs.
JD405903 - Sequence 386927 from Patent EP1572962.
JD057255 - Sequence 38279 from Patent EP1572962.
JD173423 - Sequence 154447 from Patent EP1572962.
JD203557 - Sequence 184581 from Patent EP1572962.
JD204439 - Sequence 185463 from Patent EP1572962.
DQ892224 - Synthetic construct clone IMAGE:100004854; FLH184275.01X; RZPDo839E01144D lectin, galactoside-binding, soluble, 3 binding protein (LGALS3BP) gene, encodes complete protein.
KJ891544 - Synthetic construct Homo sapiens clone ccsbBroadEn_00938 LGALS3BP gene, encodes complete protein.
KJ897128 - Synthetic construct Homo sapiens clone ccsbBroadEn_06522 LGALS3BP gene, encodes complete protein.
DQ895424 - Synthetic construct Homo sapiens clone IMAGE:100009884; FLH184271.01L; RZPDo839E01143D lectin, galactoside-binding, soluble, 3 binding protein (LGALS3BP) gene, encodes complete protein.
KU178164 - Homo sapiens lectin galactoside-binding soluble 3 binding protein isoform 1 (LGALS3BP) mRNA, partial cds.
KU178165 - Homo sapiens lectin galactoside-binding soluble 3 binding protein isoform 2 (LGALS3BP) mRNA, complete cds, alternatively spliced.
AB527304 - Synthetic construct DNA, clone: pF1KB5060, Homo sapiens LGALS3BP gene for lectin, galactoside-binding, soluble, 3 binding protein, without stop codon, in Flexi system.
LF328516 - JP 2014500723-A/136019: Polycomb-Associated Non-Coding RNAs.
MA564093 - JP 2018138019-A/136019: Polycomb-Associated Non-Coding RNAs.
JD465739 - Sequence 446763 from Patent EP1572962.
LF328518 - JP 2014500723-A/136021: Polycomb-Associated Non-Coding RNAs.
MA564095 - JP 2018138019-A/136021: Polycomb-Associated Non-Coding RNAs.
LF328519 - JP 2014500723-A/136022: Polycomb-Associated Non-Coding RNAs.
MA564096 - JP 2018138019-A/136022: Polycomb-Associated Non-Coding RNAs.
LF328520 - JP 2014500723-A/136023: Polycomb-Associated Non-Coding RNAs.
MA564097 - JP 2018138019-A/136023: Polycomb-Associated Non-Coding RNAs.
CU677946 - Synthetic construct Homo sapiens gateway clone IMAGE:100017720 5' read LGALS3BP mRNA.
LF328523 - JP 2014500723-A/136026: Polycomb-Associated Non-Coding RNAs.
MA564100 - JP 2018138019-A/136026: Polycomb-Associated Non-Coding RNAs.
CU677433 - Synthetic construct Homo sapiens gateway clone IMAGE:100017418 5' read LGALS3BP mRNA.
LF328526 - JP 2014500723-A/136029: Polycomb-Associated Non-Coding RNAs.
MA564103 - JP 2018138019-A/136029: Polycomb-Associated Non-Coding RNAs.
LF328528 - JP 2014500723-A/136031: Polycomb-Associated Non-Coding RNAs.
MA564105 - JP 2018138019-A/136031: Polycomb-Associated Non-Coding RNAs.
JD206904 - Sequence 187928 from Patent EP1572962.
JD426492 - Sequence 407516 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q08380 (Reactome details) participates in the following event(s):

R-HSA-481009 Exocytosis of platelet dense granule content
R-HSA-114608 Platelet degranulation
R-HSA-76005 Response to elevated platelet cytosolic Ca2+
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-109582 Hemostasis

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000262776.1, ENST00000262776.2, ENST00000262776.3, ENST00000262776.4, ENST00000262776.5, ENST00000262776.6, ENST00000262776.7, LG3BP_HUMAN, M2BP, NM_005567, Q08380, Q7M4S0, Q9UCH8, Q9UCH9, Q9UCI0, uc002jwh.1, uc002jwh.2, uc002jwh.3, uc002jwh.4, uc002jwh.5
UCSC ID: ENST00000262776.8
RefSeq Accession: NM_005567
Protein: Q08380 (aka LG3BP_HUMAN or L3BP_HUMAN)
CCDS: CCDS11759.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.