Human Gene LGALS3BP (ENST00000262776.8) from GENCODE V44
Description: Homo sapiens galectin 3 binding protein (LGALS3BP), mRNA. (from RefSeq NM_005567)
RefSeq Summary (NM_005567): The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000262776.8
Gencode Gene: ENSG00000108679.13
Transcript (Including UTRs)
Position: hg38 chr17:78,971,255-78,979,923 Size: 8,669 Total Exon Count: 6 Strand: -
Coding Region
Position: hg38 chr17:78,971,576-78,977,191 Size: 5,616 Coding Exon Count: 5
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: LG3BP_HUMAN
DESCRIPTION: RecName: Full=Galectin-3-binding protein; AltName: Full=Basement membrane autoantigen p105; AltName: Full=Lectin galactoside-binding soluble 3-binding protein; AltName: Full=Mac-2-binding protein; Short=MAC2BP; Short=Mac-2 BP; AltName: Full=Tumor-associated antigen 90K; Flags: Precursor;
FUNCTION: Promotes intergrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.SUBUNIT: Homodimers and homomultimers. The multimers form ring- like structures with a diameter of 30-40 nm. Binds LGALS1 and LGALS3. Binds ITGB1, COL4A1, COL5A1, COL6A1, FN1 and NID.SUBCELLULAR LOCATION: Secreted. Secreted, extracellular space, extracellular matrix.TISSUE SPECIFICITY: Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts.SIMILARITY: Contains 1 BACK (BTB/Kelch associated) domain.SIMILARITY: Contains 1 BTB (POZ) domain.SIMILARITY: Contains 1 SRCR domain.
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011705 - BACK
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR001190 - Srcr_rcpt
IPR017448 - Srcr_rcpt-rel
Pfam Domains: PF07707 - BTB And C-terminal Kelch
PF00530 - Scavenger receptor cysteine-rich domain
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on Q08380
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LF209435 - JP 2014500723-A/16938: Polycomb-Associated Non-Coding RNAs.MA445012 - JP 2018138019-A/16938: Polycomb-Associated Non-Coding RNAs.BC015761 - Homo sapiens lectin, galactoside-binding, soluble, 3 binding protein, mRNA (cDNA clone MGC:23157 IMAGE:4858122), complete cds.AK055977 - Homo sapiens cDNA FLJ31415 fis, clone NT2NE2000284, highly similar to Galectin-3-binding protein precursor.BC002403 - Homo sapiens lectin, galactoside-binding, soluble, 3 binding protein, mRNA (cDNA clone MGC:8513 IMAGE:2822371), complete cds.BC002998 - Homo sapiens lectin, galactoside-binding, soluble, 3 binding protein, mRNA (cDNA clone MGC:3900 IMAGE:2822371), complete cds.X79089 - H.sapiens mRNA for 90K product.AK307665 - Homo sapiens cDNA, FLJ97613.AK301444 - Homo sapiens cDNA FLJ53427 complete cds, highly similar to Galectin-3-binding protein precursor.AK057776 - Homo sapiens cDNA FLJ25047 fis, clone CBL03638, highly similar to Human Mac-2 binding protein mRNA.AK293183 - Homo sapiens cDNA FLJ54583 complete cds, highly similar to Galectin-3-binding protein precursor.L13210 - Human Mac-2 binding protein mRNA, complete cds.LF328513 - JP 2014500723-A/136016: Polycomb-Associated Non-Coding RNAs.MA564090 - JP 2018138019-A/136016: Polycomb-Associated Non-Coding RNAs.JD375415 - Sequence 356439 from Patent EP1572962.JD098282 - Sequence 79306 from Patent EP1572962.JD364851 - Sequence 345875 from Patent EP1572962.JD309506 - Sequence 290530 from Patent EP1572962.AK301040 - Homo sapiens cDNA FLJ53478 complete cds, highly similar to Galectin-3-binding protein precursor.JD181422 - Sequence 162446 from Patent EP1572962.AK295442 - Homo sapiens cDNA FLJ53509 complete cds, highly similar to Galectin-3-binding protein precursor.JD319090 - Sequence 300114 from Patent EP1572962.JD107783 - Sequence 88807 from Patent EP1572962.JD156368 - Sequence 137392 from Patent EP1572962.LF328514 - JP 2014500723-A/136017: Polycomb-Associated Non-Coding RNAs.MA564091 - JP 2018138019-A/136017: Polycomb-Associated Non-Coding RNAs.JD405903 - Sequence 386927 from Patent EP1572962.JD057255 - Sequence 38279 from Patent EP1572962.JD173423 - Sequence 154447 from Patent EP1572962.JD203557 - Sequence 184581 from Patent EP1572962.JD204439 - Sequence 185463 from Patent EP1572962.DQ892224 - Synthetic construct clone IMAGE:100004854; FLH184275.01X; RZPDo839E01144D lectin, galactoside-binding, soluble, 3 binding protein (LGALS3BP) gene, encodes complete protein.KJ891544 - Synthetic construct Homo sapiens clone ccsbBroadEn_00938 LGALS3BP gene, encodes complete protein.KJ897128 - Synthetic construct Homo sapiens clone ccsbBroadEn_06522 LGALS3BP gene, encodes complete protein.DQ895424 - Synthetic construct Homo sapiens clone IMAGE:100009884; FLH184271.01L; RZPDo839E01143D lectin, galactoside-binding, soluble, 3 binding protein (LGALS3BP) gene, encodes complete protein.KU178164 - Homo sapiens lectin galactoside-binding soluble 3 binding protein isoform 1 (LGALS3BP) mRNA, partial cds.KU178165 - Homo sapiens lectin galactoside-binding soluble 3 binding protein isoform 2 (LGALS3BP) mRNA, complete cds, alternatively spliced.AB527304 - Synthetic construct DNA, clone: pF1KB5060, Homo sapiens LGALS3BP gene for lectin, galactoside-binding, soluble, 3 binding protein, without stop codon, in Flexi system.LF328516 - JP 2014500723-A/136019: Polycomb-Associated Non-Coding RNAs.MA564093 - JP 2018138019-A/136019: Polycomb-Associated Non-Coding RNAs.JD465739 - Sequence 446763 from Patent EP1572962.LF328518 - JP 2014500723-A/136021: Polycomb-Associated Non-Coding RNAs.MA564095 - JP 2018138019-A/136021: Polycomb-Associated Non-Coding RNAs.LF328519 - JP 2014500723-A/136022: Polycomb-Associated Non-Coding RNAs.MA564096 - JP 2018138019-A/136022: Polycomb-Associated Non-Coding RNAs.LF328520 - JP 2014500723-A/136023: Polycomb-Associated Non-Coding RNAs.MA564097 - JP 2018138019-A/136023: Polycomb-Associated Non-Coding RNAs.CU677946 - Synthetic construct Homo sapiens gateway clone IMAGE:100017720 5' read LGALS3BP mRNA.LF328523 - JP 2014500723-A/136026: Polycomb-Associated Non-Coding RNAs.MA564100 - JP 2018138019-A/136026: Polycomb-Associated Non-Coding RNAs.CU677433 - Synthetic construct Homo sapiens gateway clone IMAGE:100017418 5' read LGALS3BP mRNA.LF328526 - JP 2014500723-A/136029: Polycomb-Associated Non-Coding RNAs.MA564103 - JP 2018138019-A/136029: Polycomb-Associated Non-Coding RNAs.LF328528 - JP 2014500723-A/136031: Polycomb-Associated Non-Coding RNAs.MA564105 - JP 2018138019-A/136031: Polycomb-Associated Non-Coding RNAs.JD206904 - Sequence 187928 from Patent EP1572962.JD426492 - Sequence 407516 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: ENST00000262776.1, ENST00000262776.2, ENST00000262776.3, ENST00000262776.4, ENST00000262776.5, ENST00000262776.6, ENST00000262776.7, LG3BP_HUMAN, M2BP, NM_005567, Q08380, Q7M4S0, Q9UCH8, Q9UCH9, Q9UCI0, uc002jwh.1, uc002jwh.2, uc002jwh.3, uc002jwh.4, uc002jwh.5UCSC ID: ENST00000262776.8RefSeq Accession: NM_005567
Protein: Q08380
(aka LG3BP_HUMAN or L3BP_HUMAN)
CCDS: CCDS11759.1
Methods, Credits, and Use Restrictions
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