Human Gene GRP (ENST00000256857.7) from GENCODE V44
Description: Homo sapiens gastrin releasing peptide (GRP), transcript variant 1, mRNA. (from RefSeq NM_002091) RefSeq Summary (NM_002091): This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. The encoded preproprotein is proteolytically processed to generate two peptides, gastrin-releasing peptide and neuromedin-C. These peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]. Gencode Transcript: ENST00000256857.7 Gencode Gene: ENSG00000134443.10 Transcript (Including UTRs) Position: hg38 chr18:59,220,158-59,230,771 Size: 10,614 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr18:59,220,266-59,230,468 Size: 10,203 Coding Exon Count: 3
ID:GRP_HUMAN DESCRIPTION: RecName: Full=Gastrin-releasing peptide; Short=GRP; Contains: RecName: Full=Neuromedin-C; AltName: Full=GRP-10; Flags: Precursor; FUNCTION: GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear (By similarity). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the bombesin/neuromedin-B/ranatensin family. SEQUENCE CAUTION: Sequence=AAA52612.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=Wikipedia; Note=Gastrin-releasing peptide entry; URL="http://en.wikipedia.org/wiki/Gastrin_releasing_peptide";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P07492
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.